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Transplantology, Volume 2, Issue 4

December 2021 - 11 articles

Cover Story: Animal models link in vitro research and first-in-man application during clinical trials. They provide substantial information in preclinical studies to assess new therapeutic interventions. Transplantation research is a discipline that largely benefits from the use of animal models, with mouse and pig models being the most frequently used models in organ transplantation research. A suitable animal model should best reflect the situation in humans, and the researcher should be aware of the similarities and limitations of the selected model. Therefore, it is crucial to select the most appropriate animal model from which extrapolations and valid conclusions can be obtained and translated into the human situation. This review provides an overview of the models frequently used in organ transplantation research. View this paper.
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Articles (11)

  • Article
  • Open Access
3,631 Views
9 Pages

An Eight-Year Followup Study after Heart Transplantation: The Relevance of Psychosocial and Psychiatric Background

  • Rubén Téllez,
  • Roberto Sánchez-González,
  • Mercè Cámara,
  • Oriol Cuñat,
  • Blanca del Hoyo-Buxo,
  • Marta Farrero,
  • Maria Angeles Castel,
  • Hugo López and
  • Luis Pintor

A heart transplantation (HT) is performed when a patient’s heart health has been severely compromised. However, the health care needs of a patient throughout the transplantation process are also significant. In order to investigate these postoperativ...

  • Article
  • Open Access
3,616 Views
13 Pages

A Retrospective Review of Calcineurin Inhibitors’ Impact on Cytomegalovirus Infections in Lung Transplant Recipients

  • Rita Nogueiras-Álvarez,
  • Víctor Manuel Mora-Cuesta,
  • José Manuel Cifrián Martínez,
  • María Ángeles de Cos Cossío and
  • María del Mar García Sáiz

Immunosuppressive therapy reduces the risk for allograft rejection but leaves recipients susceptible to infections. Cytomegalovirus (CMV) is one of the most frequent causes for infection after transplantation and increases the risk for allograft reje...

  • Review
  • Open Access
9 Citations
10,391 Views
18 Pages

Advances in Hypothermic and Normothermic Perfusion in Kidney Transplantation

  • Thomas B. Smith,
  • Michael L. Nicholson and
  • Sarah A. Hosgood

Hypothermic and normothermic machine perfusion in kidney transplantation are purported to exert a beneficial effect on post-transplant outcomes compared to the traditionally used method of static cold storage. Kidney perfusion techniques provide a wi...

  • Case Report
  • Open Access
1 Citations
3,364 Views
5 Pages

Laparoscopic Living-Donor Nephrectomy of a Horseshoe Kidney: A Case Report and Review of the Literature

  • Daniel Galvez,
  • Justin Steggerda,
  • Derrick Christopher,
  • Daniel Borja-Cacho and
  • Joseph Leventhal

We present the case of a living-donor nephrectomy of a horseshoe kidney. The recipient was a 33-year-old male with a history of end-stage renal disease secondary to IgA nephropathy. The donor was his 33-year-old partner who on preoperative cross-sect...

  • Review
  • Open Access
3 Citations
6,200 Views
14 Pages

Since the first liver transplantation operation (LT) in 1967 by Thomas Starzl, efforts to increase survival and prevent rejection have taken place. The development of calcineurin inhibitors (CNIs) in the 1980s led to a surge in survival post-transpla...

  • Review
  • Open Access
1 Citations
3,814 Views
8 Pages

Kidney Transplantation during the SARS-CoV-2 Pandemic in Israel: Experience from a Large-Volume Center

  • Aviad Gravetz,
  • Vladimir Tennak,
  • Vadym Mezhebovsky,
  • Michael Gurevich,
  • Sigal Eisner and
  • Eviatar Nesher

Coronavirus disease 2019 (COVID-19) has affected tens of millions of people globally since it was declared a pandemic by the World Health Organization on 11 March 2020. Since its outbreak in December 2019, the ongoing coronavirus COVID-19 pandemic ha...

  • Article
  • Open Access
4 Citations
3,707 Views
8 Pages

AmnioClip-Plus as Sutureless Alternative to Amniotic Membrane Transplantation to Improve Healing of Ocular Surface Disorders

  • Nicola Hofmann,
  • Anna-Katharina Salz,
  • Kristin Kleinhoff,
  • Niklas Möhle,
  • Martin Börgel,
  • Nancy Diedenhofen and
  • Katrin Engelmann

The medicinal benefits of amniotic membrane transplantation for ocular surface disorders are well accepted worldwide. Even in high-risk keratoplasties, the concomitant use of amniotic membrane has demonstrated its value in improving graft survival. H...

  • Review
  • Open Access
4,303 Views
16 Pages

Although the majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy, in 85–90% of early stage and 70–80% of advanced-stage disease cases, relapse remains a major problem. Autologous stem-cell transplantation (auto-HCT) after s...

  • Review
  • Open Access
13 Citations
8,672 Views
13 Pages

Animal Models in Allogenic Solid Organ Transplantation

  • Nadine Wenzel,
  • Rainer Blasczyk and
  • Constanca Figueiredo

Animal models provide the link between in vitro research and the first in-man application during clinical trials. They provide substantial information in preclinical studies for the assessment of new therapeutic interventions in advance of human clin...

  • Review
  • Open Access
4,341 Views
9 Pages

Lung transplantation offers a lifesaving therapy for patients with end-stage lung disease but its availability is presently limited by low organ utilization rates with donor lungs frequently excluded due to unsuitability at assessment. When transplan...

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Transplantology - ISSN 2673-3943