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Transplantology, Volume 6, Issue 4

2025 December - 10 articles

Cover Story: We conducted a retrospective case series of five adult lung transplant recipients (LTRs) converted to belatacept with CNI elimination between 2020 and 2023 with a median follow up of 3.49 years (IQR 16.4). Post-conversion, eGFR improved with a median change of +18 mL/min/1.73 m2 (IQR 6–34) at 12 months. Force expiratory volume in 1 s (FEV1) declined from baseline to last follow-up (median change −0.53 L). At a median of 199 days post-conversion (IQR 108–453), belatacept was discontinued in 4/5 (80%) LTR, primarily due to graft dysfunction (3/4), and CNI therapy resumed. Belatacept with complete CNI elimination in LTR resulted in a sustained improvement in renal function in this series but was accompanied by a high discontinuation rate due to worsening graft function. View this paper
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Articles (10)

  • Article
  • Open Access
2,143 Views
16 Pages

Background: Minimally invasive techniques for living donor nephrectomy are crucial for donor safety and promoting organ donation. Hand-Assisted Retroperitoneoscopic Donor Nephrectomy (HARP-DN) combines the benefits of minimally invasive surgery with...

(This article belongs to the Section Living Donors and Mini Invasive Surgery)
  • Case Report
  • Open Access
2,274 Views
13 Pages

Background: Lung cancer is one of the leading cancers worldwide in mortality and incidence. Treating advanced stages of lung cancer is a great problem because of high metastatic potential and low adherence to common monotherapies such as radiation or...

(This article belongs to the Section Transplant Immunology and Immunosuppressive Drugs)
  • Article
  • Open Access
1 Citations
2,458 Views
12 Pages

Purpose: This study aimed to examine post-traumatic growth, mindfulness, and quality of life in recipients after liver transplantation. Design and Methods: This study employs a descriptive and cross-sectional design. We collected data in an organ tra...

(This article belongs to the Section Transplant Immunology and Immunosuppressive Drugs)
  • Review
  • Open Access
3 Citations
4,335 Views
34 Pages

Metabolic dysfunction–associated fatty liver disease (MAFLD) is now the leading indication for liver transplantation (LT), reshaping the landscape of transplant hepatology. Its close association with obesity, type 2 diabetes, cardiovascular dis...

(This article belongs to the Special Issue New Horizons in Transplantation Research: A Review Series)
  • Article
  • Open Access
1,980 Views
10 Pages

Epitope Specificity of HLA Class I Alloantibodies in Indian Renal Transplant Patients: A Single-Center Study

  • Vikash Chandra Mishra,
  • Dinesh Chandra,
  • Ritu Sharma,
  • Diksha Dhuliya and
  • Vimarsh Raina

Background/Objectives: Epitope-based matching has emerged as a refined approach for assessing donor–recipient compatibility in renal transplantation. However, limited data are available on HLA Class I epitope distribution among Indian patients,...

(This article belongs to the Section Solid Organ Transplantation)
  • Editorial
  • Open Access
2,552 Views
5 Pages

Chronic kidney disease (CKD) remains one of the most frequent long-term complications following liver transplantation, with calcineurin inhibitor nephrotoxicity as an important and modifiable driver [...]

(This article belongs to the Section Solid Organ Transplantation)
  • Article
  • Open Access
1 Citations
1,486 Views
11 Pages

Arterial Stiffness in Kidney Transplant Recipients: A Cross-Sectional Tunisian Study

  • Hiba Ghabi,
  • Amira Khemiri,
  • Ikram Mami,
  • Syrine Tlili,
  • Jihen Sahli,
  • Fethi Ben Hmida,
  • Lamia Rais and
  • Mouhamed Karim Zouaghi

Background: Arterial stiffness assessed by measuring pulse wave velocity (PWV) is a well-established predictor of cardiovascular mortality. To our knowledge, no studies on arterial stiffness in kidney transplant recipients (KTRs) from Tunisia have be...

(This article belongs to the Section Solid Organ Transplantation)
  • Article
  • Open Access
2,960 Views
10 Pages

Belatacept-Based Immunosuppression in Lung Transplant Recipients with Calcineurin Inhibitor Renal Toxicities

  • Krysta Walter,
  • Alisia Chen,
  • Jennifer Hagopian,
  • Elizabeth Belloli,
  • Michael Combs,
  • Dennis Lyu and
  • Rommel Sagana

Background/Objectives: Calcineurin inhibitors (CNI) contribute to renal dysfunction post-transplant. Belatacept is a renal sparing immunosuppressive agent. We sought to determine if the use of belatacept, as an alternative to a CNI-based maintenance...

(This article belongs to the Section Solid Organ Transplantation)
  • Article
  • Open Access
2,306 Views
12 Pages

Background: Post-transplant diabetes mellitus (PTDM) is a complication of kidney transplantation, but the impact of early hyperglycemia (EH) remains unclear. This study aimed to assess the incidence of PTDM in kidney transplant recipients (KTRs) who...

(This article belongs to the Section Perioperative Patient Management (i.e. Preabilitation, Intensive Care Management, Complications))
  • Case Report
  • Open Access
2 Citations
2,203 Views
15 Pages

Successful Experience of Managing Resistant Antibody-Mediated Cardiac Allograft Rejection with Extracorporeal Photopheresis

  • Lubov Korneva,
  • Yulia Sazonova,
  • Maria Bortsova,
  • Maria Simonenko,
  • Georgii Baratashvili,
  • Olga Kalinina,
  • Ekaterina Zaikova,
  • Darina Sambur,
  • Alexey Golovkin and
  • Petr Fedotov

Background/Clinical Significance: Development of acute antibody-mediated rejection (AMR) of allograft is one of the leading causes of mortality in heart-transplant recipients; however, the standard therapy does not always resolve severe forms of reje...

(This article belongs to the Section Transplant Immunology and Immunosuppressive Drugs)
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Transplantology - ISSN 2673-3943