Next Article in Journal
Review of Outcomes after Diagnosis of Malignancy in Kidney Transplant Patients: UNOS Database
Next Article in Special Issue
Mental Health and Well-Being of Solid Organ Transplant Donors. The Forgotten Sacrifices
Previous Article in Journal
Clinical Characteristics, Treatments and Outcomes of 18 Lung Transplant Recipients with COVID-19
Previous Article in Special Issue
“You Can’t Manage What You Can’t Measure”: Perspectives of Transplant Recipients on Two Lifestyle Interventions for Weight Management
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Transplantology
Volume 2
Issue 3
10.3390/transplantology2030023
transplantology-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Direct Alcohol Biomarkers Prediction Capacity on Relapse and Mortality in Liver Transplantation Candidates: A Follow-Up Study

by
Pablo Barrio
1,*,
Oriol Marco
2,
Mauro Druetta
2,
Laia Tardon
2,
Anna Lligonya
1,
Friedrich Martin Wurst
3,
Wolfgang Weinmann
4,
Michel Yegles
5 and
Antoni Gual
1
1
Grup Recerca Addiccions Clínic (GRAC-GRE), Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic Barcelona, Carrer villarroel 170, 08036 Barcelona, Spain
2
Servei de Psiquiatriai Psicologia, Hospital Clínic de Barcelona, 08036 Barcelona, Spain
3
Psychiatric University Hospital, 4002 Basel, Switzerland
4
Institute of Forensic Medicine, University of Bern, 3012 Bern, Switzerland
5
Service de Toxicologie, LaboratoireNational de Santé, 3555 Dudelange, Luxembourg
*
Author to whom correspondence should be addressed.
Transplantology 2021, 2(3), 246-252; https://doi.org/10.3390/transplantology2030023
Submission received: 31 May 2021 / Revised: 10 June 2021 / Accepted: 21 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue Mental Health and Transplantation: Challenges and Solutions)
Browse Figures
Versions Notes

Abstract

Liver transplantation is a complex procedure that requires multiple evaluations, including abstinence monitorization. While literature assessing the impact of different variables on relapse, survival, and graft loss exists, little is known about the predictive capacity of direct alcohol biomarkers. The primary aim of this study was to evaluate the prediction capacity of direct alcohol biomarkers regarding patient survival and clinical relapse. We hypothesized that patients screening positive for any of the experimental biomarkers would show an increased risk of clinical alcohol relapse and death. We conducted a retrospective data recollection from medical files of patients awaiting liver transplantation, who were at baseline screened with Peth, EtG in hair and urine, and EtS. We tested the prediction capacity of the biomarkers with two Cox-regression models. A total of 50 patients were included (84% men, mean age 59 years (SD = 6)). Biomarkers at baseline were positive in 18 patients. The mean follow-up time for this study was 26 months (SD = 10.4). Twelve patients died, liver transplantation was carried out in 12 patients, and clinical relapse was observed in eight patients. The only significant covariate in the Cox-regression models was age with clinical relapse, with younger patients being at greater risk of relapse. This study could not find a significant prediction capacity of direct alcohol biomarkers for mortality or clinical relapse during follow-up. Higher sample sizes might be needed to detect statistically significant differences. All in all, we believe that direct alcohol biomarkers should be widely used in liver transplantation settings due to their high sensitivity for the detection of recent drinking.
Keywords: alcohol biomarkers; liver transplantation; alcohol dependence alcohol biomarkers; liver transplantation; alcohol dependence
Graphical Abstract

Share and Cite

MDPI and ACS Style

Barrio, P.; Marco, O.; Druetta, M.; Tardon, L.; Lligonya, A.; Wurst, F.M.; Weinmann, W.; Yegles, M.; Gual, A. Direct Alcohol Biomarkers Prediction Capacity on Relapse and Mortality in Liver Transplantation Candidates: A Follow-Up Study. Transplantology 2021, 2, 246-252. https://doi.org/10.3390/transplantology2030023

AMA Style

Barrio P, Marco O, Druetta M, Tardon L, Lligonya A, Wurst FM, Weinmann W, Yegles M, Gual A. Direct Alcohol Biomarkers Prediction Capacity on Relapse and Mortality in Liver Transplantation Candidates: A Follow-Up Study. Transplantology. 2021; 2(3):246-252. https://doi.org/10.3390/transplantology2030023

Chicago/Turabian Style

Barrio, Pablo, Oriol Marco, Mauro Druetta, Laia Tardon, Anna Lligonya, Friedrich Martin Wurst, Wolfgang Weinmann, Michel Yegles, and Antoni Gual. 2021. "Direct Alcohol Biomarkers Prediction Capacity on Relapse and Mortality in Liver Transplantation Candidates: A Follow-Up Study" Transplantology 2, no. 3: 246-252. https://doi.org/10.3390/transplantology2030023

APA Style

Barrio, P., Marco, O., Druetta, M., Tardon, L., Lligonya, A., Wurst, F. M., Weinmann, W., Yegles, M., & Gual, A. (2021). Direct Alcohol Biomarkers Prediction Capacity on Relapse and Mortality in Liver Transplantation Candidates: A Follow-Up Study. Transplantology, 2(3), 246-252. https://doi.org/10.3390/transplantology2030023

Article Metrics

Back to TopTop