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New Antimicrobial Strategies Based on Metal Complexes

Department of Chemistry, University of Fribourg, Chemin du Musée 9, CH-1700 Fribourg, Switzerland
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Chemistry 2020, 2(4), 849-899; https://doi.org/10.3390/chemistry2040056
Received: 13 August 2020 / Revised: 9 October 2020 / Accepted: 12 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue 2020 Profile Papers by Chemistry' Editorial Board Members)
Traditional organic antimicrobials mainly act on specific biochemical processes such as replication, transcription and translation. However, the emergence and wide spread of microbial resistance is a growing threat for human beings. Therefore, it is highly necessary to design strategies for the development of new drugs in order to target multiple cellular processes that should improve their efficiency against several microorganisms, including bacteria, viruses or fungi. The present review is focused on recent advances and findings of new antimicrobial strategies based on metal complexes. Recent studies indicate that some metal ions cause different types of damages to microbial cells as a result of membrane degradation, protein dysfunction and oxidative stress. These unique modes of action, combined with the wide range of three-dimensional geometries that metal complexes can adopt, make them suitable for the development of new antimicrobial drugs. View Full-Text
Keywords: metal complexes; new antimicrobial strategies; metallo-drugs; silver; copper; zinc; iron; ruthenium; gallium; bismuth; vanadium; synergic effects metal complexes; new antimicrobial strategies; metallo-drugs; silver; copper; zinc; iron; ruthenium; gallium; bismuth; vanadium; synergic effects
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Claudel, M.; Schwarte, J.V.; Fromm, K.M. New Antimicrobial Strategies Based on Metal Complexes. Chemistry 2020, 2, 849-899.

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