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Quest for Bioactive Compounds in Our Diet with Anti-Ageing and Anti-Aggregation Properties

Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35 Athens, Greece
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Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg 25–27 March 2019.
Proceedings 2019, 11(1), 34; https://doi.org/10.3390/proceedings2019011034
Published: 29 April 2019
PDF [198 KB, uploaded 29 April 2019]

Abstract

Ageing is a complex process affected by both genetic and environmental factors, characterized by a gradual failure of functionality, reduced stress response and resistance, leading to enhanced probability for age-related diseases and mortality. During the last decades, natural compounds have attracted the attention of researchers in the quest of bioactive phytochemicals with anti-ageing properties. For a few of these compounds an extra advantage appears; many of them have been shown to decelerate the progression of age-related diseases with emphasis on aggregation-related diseases. Using the nematode Caenorhabditis elegans along with the replicative senescence model of human primary fibroblasts, we have identified compounds that are part of our diet with anti-oxidation, anti-ageing and anti-aggregation activities. Some of the identified compounds promote their anti-ageing activity through activation of the proteasome, others through the activation of Nrf2 transcription factor, while others through inhibition of glucose transporters (GLUTs). Our work identifies new bioactive compounds with anti-ageing and/or anti-aggregation properties or reveals additional beneficial properties on already known bioactive compounds.
Keywords: anti-ageing; anti-aggregation; anti-oxidation; bioactive compounds; proteasome; Nrf2; glucose transporters anti-ageing; anti-aggregation; anti-oxidation; bioactive compounds; proteasome; Nrf2; glucose transporters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Papaevgeniou, N.; Panagiotidou, E.; Filippopoulou, K.; Chondrogianni, N. Quest for Bioactive Compounds in Our Diet with Anti-Ageing and Anti-Aggregation Properties. Proceedings 2019, 11, 34.

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