Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes
AbstractThere are a number of different animals that belong to long- and short-lived species and show a various rate of ageing, providing an ideal model to investigate mechanisms of longevity. In this work, a metabolome profiling of blood plasma from fishes with various ageing rates—negligible (Pike Esox Lucius and Sterlet Acipenser ruthenus), gradual (Zander Sander lucioperca and Perch Perca fluviatilis) and rapid (Chum Salmon Oncorhynchus keta and Pink Salmon Oncorhynchus gorbuscha)—was assessed by means of direct infusion to quadrupole time-of-flight mass spectrometry. Of the 2056 distinct m/z features detected by a mass spectrometry metabolic profiling of blood plasma samples, fifteen metabolites in the classes of dipeptides, fatty acids, glycerolipids, phosphoethanolamines and phosphatidylcholines were significantly associated with ageing rate, independent of species differences. This is the first study of the metabolome of fishes with various ageing rate, and this untargeted approach highlighted the metabolic conditions that may serve to assess the ageing process. View Full-Text
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Trifonova, O.P.; Maslov, D.L.; Mikhailov, A.N.; Zolotarev, K.V.; Nakhod, K.V.; Nakhod, V.I.; Belyaeva, N.F.; Mikhailova, M.V.; Lokhov, P.G.; Archakov, A.I. Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes. Fishes 2018, 3, 46.
Trifonova OP, Maslov DL, Mikhailov AN, Zolotarev KV, Nakhod KV, Nakhod VI, Belyaeva NF, Mikhailova MV, Lokhov PG, Archakov AI. Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes. Fishes. 2018; 3(4):46.Chicago/Turabian Style
Trifonova, Oxana P.; Maslov, Dmitry L.; Mikhailov, Anton N.; Zolotarev, Konstantin V.; Nakhod, Kirill V.; Nakhod, Valeriya I.; Belyaeva, Nataliya F.; Mikhailova, Marina V.; Lokhov, Petr G.; Archakov, Alexander I. 2018. "Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes." Fishes 3, no. 4: 46.