Methods and Protocols, Volume 5, Issue 6
2022 December - 17 articles
Cover Story: During the first wave of COVID-19, there was uncertainty about the frequency of secondary bacterial infection requiring antibiotic therapy and concern about overuse of antibiotics. Procalcitonin (PCT), an inflammatory marker used to guide antibiotic treatment, was widely adopted early in the pandemic, with some evidence that it reduced antibiotic use. This protocol is for a retrospective, cohort study to compare antibiotic use and patient outcomes in those who did and did not have a baseline PCT test when COVID-19 was diagnosed. Clinical data from patients with a positive COVID-19 test 1/2/20-30/6/20 and admitted to 11 acute hospital Trusts and Health Boards in England and Wales will be eligible. Primary outcome is early antibiotic use (first 7 days); secondary outcomes include total antibiotic use, length of stay and mortality. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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