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Open AccessProtocol

Protocol for Construction of Rat Nerve Stimulation Cuff Electrodes

1
School of Brain and Behavioral Sciences, The University of Texas at Dallas, Richardson, TX 75080-3021, USA
2
School of Biomedical Engineering, The University of Texas at Dallas, Richardson, TX 75080-3021, USA
3
Texas Biomedical Device Center (TxBDC), The University of Texas at Dallas, Richardson, TX 75080-3021, USA
*
Author to whom correspondence should be addressed.
Methods Protoc. 2019, 2(1), 19; https://doi.org/10.3390/mps2010019
Received: 10 January 2019 / Revised: 30 January 2019 / Accepted: 12 February 2019 / Published: 15 February 2019
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PDF [7215 KB, uploaded 27 February 2019]
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Abstract

Peripheral nerve stimulation has emerged as a platform therapy to treat a wide range of disorders. Continued development and translation of these strategies requires that researchers have access to reliable, customizable electrodes for nerve stimulation. Here, we detail procedures to build three different configurations of cuff electrodes with varying numbers and orientations of contacts for nerve stimulation in rats. These designs are built with simple, widely available materials, using platinum–iridium electrodes assembled into polyurethane tubing. Moreover, the designs can easily be customized to increase versatility and individualize for specific stimulation applications. This protocol provides a resource to facilitate the construction and customization of stimulation cuffs to support preclinical nerve stimulation research.
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Keywords: vagus nerve stimulation; vagus nerve; cuff electrode; micro-construction; vagal nerve vagus nerve stimulation; vagus nerve; cuff electrode; micro-construction; vagal nerve
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rios, M.U.; Bucksot, J.E.; Rahebi, K.C.; Engineer, C.T.; Kilgard, M.P.; Hays, S.A. Protocol for Construction of Rat Nerve Stimulation Cuff Electrodes. Methods Protoc. 2019, 2, 19.

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