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Biomimetics
Volume 9
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10.3390/biomimetics9050294
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Review

Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery

by
Toshiyuki Kunisada
1,2,*,
Eiji Nakata
2,
Tomohiro Fujiwara
2,
Toshiaki Hata
2,
Kohei Sato
2,
Haruyoshi Katayama
2,
Ayana Kondo
2 and
Toshifumi Ozaki
2
1
Department of Medical Materials for Musculoskeletal Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan
2
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan
*
Author to whom correspondence should be addressed.
Biomimetics 2024, 9(5), 294; https://doi.org/10.3390/biomimetics9050294
Submission received: 15 April 2024 / Revised: 10 May 2024 / Accepted: 13 May 2024 / Published: 15 May 2024
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration)
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Abstract

Unidirectional porous hydroxyapatite (UDPHAp) was developed as a remarkable scaffold characterized by a distinct structure with unidirectional pores oriented in the horizontal direction and connected through interposes. We evaluated the radiographic changes, clinical outcomes, and complications following UDPHAp implantation for the treatment of bone tumors. Excellent bone formation within and around the implant was observed in all patients treated with intralesional resection and UDPHAp implantation for benign bone tumors. The absorption of UDPHAp and remodeling of the bone marrow space was observed in 45% of the patients at a mean of 17 months postoperatively and was significantly more common in younger patients. Preoperative cortical thinning was completely regenerated in 84% of patients at a mean of 10 months postoperatively. No complications related to the implanted UDPHAp were observed. In a pediatric patient with bone sarcoma, when the defect after fibular resection was filled with UDPHAp implants, radiography showed complete resorption of the implant and clear formation of cortex and marrow in the resected part of the fibula. The patient could walk well without crutches and participate in sports activities. UDPHAp is a useful bone graft substitute for the treatment of benign bone tumors, and the use of this material has a low complication rate. We also review and discuss the potential of UDPHAp as a bone graft substitute in the clinical setting of orthopedic surgery.
Keywords: hydroxyapatite; bone tumor; orthopedic surgery; unidirectional porous hydroxyapatite; bone graft hydroxyapatite; bone tumor; orthopedic surgery; unidirectional porous hydroxyapatite; bone graft

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MDPI and ACS Style

Kunisada, T.; Nakata, E.; Fujiwara, T.; Hata, T.; Sato, K.; Katayama, H.; Kondo, A.; Ozaki, T. Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery. Biomimetics 2024, 9, 294. https://doi.org/10.3390/biomimetics9050294

AMA Style

Kunisada T, Nakata E, Fujiwara T, Hata T, Sato K, Katayama H, Kondo A, Ozaki T. Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery. Biomimetics. 2024; 9(5):294. https://doi.org/10.3390/biomimetics9050294

Chicago/Turabian Style

Kunisada, Toshiyuki, Eiji Nakata, Tomohiro Fujiwara, Toshiaki Hata, Kohei Sato, Haruyoshi Katayama, Ayana Kondo, and Toshifumi Ozaki. 2024. "Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery" Biomimetics 9, no. 5: 294. https://doi.org/10.3390/biomimetics9050294

APA Style

Kunisada, T., Nakata, E., Fujiwara, T., Hata, T., Sato, K., Katayama, H., Kondo, A., & Ozaki, T. (2024). Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery. Biomimetics, 9(5), 294. https://doi.org/10.3390/biomimetics9050294

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