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Review

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

by
Mauro Pollini
1,2,* and
Federica Paladini
1,2,*
1
Department of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, Italy
2
Caresilk S.r.l.s., Via Monteroni c/o Technological District DHITECH, 73100 Lecce, Italy
*
Authors to whom correspondence should be addressed.
Biomimetics 2024, 9(5), 295; https://doi.org/10.3390/biomimetics9050295
Submission received: 7 April 2024 / Revised: 1 May 2024 / Accepted: 9 May 2024 / Published: 15 May 2024
(This article belongs to the Special Issue Silk-Based Bioinspired Materials: Design and Applications)

Abstract

In order to reduce the toxicological impact on healthy cells and to improve the therapeutic response, many drug delivery systems have been fabricated and analysed, involving the use of different natural and synthetic materials at macro-, micro- and nanoscales. Among the natural materials which have demonstrated a huge potential for the development of effective drug delivery systems, silk fibroin has emerged for its excellent biological properties and for the possibility to be processed in a wide range of forms, which can be compliant with multiple active molecules and pharmaceutical ingredients for the treatment of various diseases. This review aims at presenting silk fibroin as an interesting biopolymer for applications in drug delivery systems, exploring the results obtained in recent works in terms of technological progress and effectiveness in vitro and in vivo.
Keywords: drug delivery; silk fibroin; biomaterials; biopolymers drug delivery; silk fibroin; biomaterials; biopolymers

Share and Cite

MDPI and ACS Style

Pollini, M.; Paladini, F. The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems. Biomimetics 2024, 9, 295. https://doi.org/10.3390/biomimetics9050295

AMA Style

Pollini M, Paladini F. The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems. Biomimetics. 2024; 9(5):295. https://doi.org/10.3390/biomimetics9050295

Chicago/Turabian Style

Pollini, Mauro, and Federica Paladini. 2024. "The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems" Biomimetics 9, no. 5: 295. https://doi.org/10.3390/biomimetics9050295

APA Style

Pollini, M., & Paladini, F. (2024). The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems. Biomimetics, 9(5), 295. https://doi.org/10.3390/biomimetics9050295

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