Next Article in Journal
Intelligent Breast Mass Classification Approach Using Archimedes Optimization Algorithm with Deep Learning on Digital Mammograms
Next Article in Special Issue
Customized Subperiosteal Implants for the Rehabilitation of Atrophic Jaws: A Consensus Report and Literature Review
Previous Article in Journal
YOLO-DRS: A Bioinspired Object Detection Algorithm for Remote Sensing Images Incorporating a Multi-Scale Efficient Lightweight Attention Mechanism
Previous Article in Special Issue
Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomimetics
Volume 8
Issue 6
10.3390/biomimetics8060461
biomimetics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Comparison of Prophylactic Effects between Localized Biomimetic Minocycline and Systematic Amoxicillin on Implants Placed Immediately in Infected Sockets

by
Won-Woo Lee
1,†,
Jin-Won Seo
1,†,
Il-Seok Jang
2,
Young-Joong Kwon
2,
Won-Jun Joung
1,
Jong-Hun Jun
1,
Jiyeong Kim
3,
Donghee Son
4,
Seung-Weon Lim
5,
Seo-Hyoung Yun
1,
Marco Tallarico
6 and
Chang-Joo Park
1,*
1
Division of Oral & Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
2
Osstem R&D Center, Seoul 07789, Republic of Korea
3
Department of Pre-Medicine, College of Medicine and Biostatistics Lab, Medical Research Collaborating Center (MRCC), Hanyang University, Seoul 04763, Republic of Korea
4
Laboratory of Biostatistical Consulting and Research, Medical Research Collaborating Center, Industry-University Cooperation Foundation, Hanyang University, Seoul 04763, Republic of Korea
5
Division of Orthodontics, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
6
Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07021 Sassari, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomimetics 2023, 8(6), 461; https://doi.org/10.3390/biomimetics8060461
Submission received: 18 August 2023 / Revised: 17 September 2023 / Accepted: 18 September 2023 / Published: 1 October 2023
(This article belongs to the Special Issue Dentistry and Cranio Facial District: The Role of Biomimetics)
Browse Figures
Review Reports Versions Notes

Abstract

This study evaluated the prophylactic effect of localized biomimetic minocycline and systemic amoxicillin on immediate implant placement at infected extraction sites. Twelve mongrels with six implants each were randomly assigned to five groups: uninfected negative control (Group N); infected with oral complex bacteria (Group P); infected and treated with amoxicillin one hour before implant placement (Group A); infected and treated with minocycline during implant placement (Group B); and infected and treated with amoxicillin one hour before implant placement and with minocycline during implant placement (Group C). Radiographic bone level, gingival index (GI), probing depth (PD), papillary bleeding index (PBI), and removal torque (RT) were recorded. There was no significant difference between Groups A, B, and C for bone loss. Group A showed the highest RT, the lowest PBI, and significantly lower GI and PD values than Group P. Group B exhibited significantly higher RT value than Group N and significantly smaller PD value than Group P at 6 w postoperatively. Localized minocycline could improve implant success by reducing bone loss and increasing RT and systemic amoxicillin could maintain the stability of the peri-implant soft tissue. However, combined use of these two antibiotics did not augment the prophylactic effect.
Keywords: amoxicillin; immediate implant placement; implant success; minocycline amoxicillin; immediate implant placement; implant success; minocycline

Share and Cite

MDPI and ACS Style

Lee, W.-W.; Seo, J.-W.; Jang, I.-S.; Kwon, Y.-J.; Joung, W.-J.; Jun, J.-H.; Kim, J.; Son, D.; Lim, S.-W.; Yun, S.-H.; et al. Comparison of Prophylactic Effects between Localized Biomimetic Minocycline and Systematic Amoxicillin on Implants Placed Immediately in Infected Sockets. Biomimetics 2023, 8, 461. https://doi.org/10.3390/biomimetics8060461

AMA Style

Lee W-W, Seo J-W, Jang I-S, Kwon Y-J, Joung W-J, Jun J-H, Kim J, Son D, Lim S-W, Yun S-H, et al. Comparison of Prophylactic Effects between Localized Biomimetic Minocycline and Systematic Amoxicillin on Implants Placed Immediately in Infected Sockets. Biomimetics. 2023; 8(6):461. https://doi.org/10.3390/biomimetics8060461

Chicago/Turabian Style

Lee, Won-Woo, Jin-Won Seo, Il-Seok Jang, Young-Joong Kwon, Won-Jun Joung, Jong-Hun Jun, Jiyeong Kim, Donghee Son, Seung-Weon Lim, Seo-Hyoung Yun, and et al. 2023. "Comparison of Prophylactic Effects between Localized Biomimetic Minocycline and Systematic Amoxicillin on Implants Placed Immediately in Infected Sockets" Biomimetics 8, no. 6: 461. https://doi.org/10.3390/biomimetics8060461

APA Style

Lee, W.-W., Seo, J.-W., Jang, I.-S., Kwon, Y.-J., Joung, W.-J., Jun, J.-H., Kim, J., Son, D., Lim, S.-W., Yun, S.-H., Tallarico, M., & Park, C.-J. (2023). Comparison of Prophylactic Effects between Localized Biomimetic Minocycline and Systematic Amoxicillin on Implants Placed Immediately in Infected Sockets. Biomimetics, 8(6), 461. https://doi.org/10.3390/biomimetics8060461

Article Metrics

Back to TopTop