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Non-Coding RNA, Volume 9, Issue 3

2023 June - 6 articles

Cover Story: The cellular roles of circular RNAs (circRNAs) are widely studied; albeit little is known about the effects of drugs on their expression and relationship with the cognate linear transcript (linRNA). Focusing on breast cancer, we tested various anticancer agents in two cell lines that comprise a panel of drug-modulated circRNAs/linRNAs. According to their oncogenic or anticancer role, we observed the upregulation of circRNA and downregulation of linRNA within the same gene in association with specific mutated pathways, such as PI3K/AKT in MCF-7 or the NHEJ DNA repair pathway in the TP53-mutated MDA-MB-231 cell. Interestingly, only XL765 did not alter tumorigenic circ/linRNAs in MCF-7, and AMG511 and GSK1070916 decreased circGFRA1, as drug effectiveness in MDA-MB-231 cells. View this paper
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Articles (6)

  • Commentary
  • Open Access
6 Citations
3,307 Views
7 Pages

The ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome. These modifications occur in functionally important regions of t...

  • Feature Paper
  • Review
  • Open Access
7 Citations
3,486 Views
20 Pages

A Review of IsomiRs in Colorectal Cancer

  • Molly A. Lausten and
  • Bruce M. Boman

As advancements in sequencing technology rapidly continue to develop, a new classification of microRNAs has occurred with the discovery of isomiRs, which are relatively common microRNAs with sequence variations compared to their established template...

  • Communication
  • Open Access
2 Citations
3,156 Views
10 Pages

A microRNA Arising from the Negative Strand of SARS-CoV-2 Genome Targets FOS to Reduce AP-1 Activity

  • Francesco Greco,
  • Elisa Lorefice,
  • Claudia Carissimi,
  • Ilaria Laudadio,
  • Fabiola Ciccosanti,
  • Martina Di Rienzo,
  • Francesca Colavita,
  • Silvia Meschi,
  • Fabrizio Maggi and
  • Valerio Fulci
  • + 1 author

Virus-encoded microRNAs were first reported in the Epstein–Barr virus in 2004. Subsequently, a few hundred viral miRNAs have been identified, mainly in DNA viruses belonging to the herpesviridae family. To date, only 30 viral miRNAs encoded by...

  • Article
  • Open Access
1 Citations
3,660 Views
16 Pages

Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines

  • Anna Terrazzan,
  • Francesca Crudele,
  • Fabio Corrà,
  • Pietro Ancona,
  • Jeffrey Palatini,
  • Nicoletta Bianchi and
  • Stefano Volinia

Altered expression of circular RNAs (circRNAs) has previously been investigated in breast cancer. However, little is known about the effects of drugs on their regulation and relationship with the cognate linear transcript (linRNA). We analyzed the dy...

  • Article
  • Open Access
2 Citations
3,909 Views
13 Pages

Genetic Deletion of the LINC00520 Homolog in Mouse Aggravates Angiotensin II-Induced Hypertension

  • Xiaofang Tang,
  • Chih-Hung Lai,
  • Naseeb K. Malhi,
  • Rahuljeet Chadha,
  • Yingjun Luo,
  • Xuejing Liu,
  • Dongqiang Yuan,
  • Alonso Tapia,
  • Maryam Abdollahi and
  • Zhen Bouman Chen
  • + 7 authors

(1) Background: Hypertension is a complex, multifactorial disease that is caused by genetic and environmental factors. Apart from genetic predisposition, the mechanisms involved in this disease have yet to be fully understood. We previously reported...

  • Feature Paper
  • Article
  • Open Access
7 Citations
5,085 Views
20 Pages

T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes

  • Rebecca Distefano,
  • Mirolyuba Ilieva,
  • Jens Hedelund Madsen,
  • Hideshi Ishii,
  • Masanori Aikawa,
  • Sarah Rennie and
  • Shizuka Uchida

Type II diabetes (T2D) is a growing health problem worldwide due to increased levels of obesity and can lead to other life-threatening diseases, such as cardiovascular and kidney diseases. As the number of individuals diagnosed with T2D rises, there...

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Non-Coding RNA - ISSN 2311-553X