Next Article in Journal
Suppressors of Meiotic Silencing by Unpaired DNA
Next Article in Special Issue
Circulating microRNAs and Their Role in Multiple Myeloma
Previous Article in Journal
Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology
Previous Article in Special Issue
Factors Regulating microRNA Expression and Function in Multiple Myeloma
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview

Long Non-Coding RNAs in Multiple Myeloma

1
Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
2
Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, 60200 Brno, Czech Republic
3
Department of Hematooncology, University Hospital Ostrava and Faculty of Medicine, University Ostrava, 70852 Ostrava, Czech Republic
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Non-Coding RNA 2019, 5(1), 13; https://doi.org/10.3390/ncrna5010013
Received: 16 November 2018 / Revised: 15 January 2019 / Accepted: 15 January 2019 / Published: 24 January 2019
(This article belongs to the Special Issue Non-Coding RNA in Multiple Myeloma)
  |  
PDF [638 KB, uploaded 16 February 2019]
  |  

Abstract

Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers. View Full-Text
Keywords: multiple myeloma; long non-coding RNAs; biomarker multiple myeloma; long non-coding RNAs; biomarker
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Butova, R.; Vychytilova-Faltejskova, P.; Souckova, A.; Sevcikova, S.; Hajek, R. Long Non-Coding RNAs in Multiple Myeloma. Non-Coding RNA 2019, 5, 13.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Non-Coding RNA EISSN 2311-553X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top