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Contributions of the Biofilm Matrix to Candida Pathogenesis

Departments of Medicine and Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA
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J. Fungi 2020, 6(1), 21; https://doi.org/10.3390/jof6010021
Received: 9 January 2020 / Revised: 29 January 2020 / Accepted: 30 January 2020 / Published: 3 February 2020
(This article belongs to the Special Issue Pathogenesis of Candidiasis)
In healthcare settings, Candida spp. cause invasive disease with high mortality. The overwhelming majority of cases are associated with the use of critically-needed medical devices, such as vascular catheters. On the surface of these indwelling materials, Candida forms resilient, adherent biofilm communities. A hallmark characteristic of this process is the production of an extracellular matrix, which promotes fungal adhesion and provides protection from external threats. In this review, we highlight the medical relevance of device-associated Candida biofilms and draw attention to the process of Candida-biofilm-matrix production. We provide an update on the current understanding of how biofilm extracellular matrix contributes to pathogenicity, particularly through its roles in the promoting antifungal drug tolerance and immune evasion. View Full-Text
Keywords: Candida; matrix; biofilm; immunity; drug resistance Candida; matrix; biofilm; immunity; drug resistance
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Nett, J.E.; Andes, D.R. Contributions of the Biofilm Matrix to Candida Pathogenesis. J. Fungi 2020, 6, 21.

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