The fungal pathogens Cryptococcus neoformans
and Cryptococcus gattii
can cause life-threatening infections in immune compromised and immune competent hosts. These pathogens enter the host via inhalation, and respiratory tract innate immune cells such as dendritic cells (DCs) are one of the first host cells they encounter. The interactions between Cryptococcus
and innate immune cells play a critical role in the progression of disease in the host. This review will focus specifically on the interactions between Cryptococcus
and dendritic cells (DCs), including recognition/processing by DCs, effects of immune mediators on DC recruitment and activity, and the potential for DC vaccination against cryptococcosis.
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