Next Article in Journal
From a Few Cardiovascular Risk Factors to the Prediction of Age at Death: The Shifting Interests of Cardiovascular Epidemiologists
Previous Article in Journal
Spinal Cord Stimulation for Refractory Angina Pectoris: Current Status and Future Perspectives, a Narrative Review
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCDD
Volume 12
Issue 2
10.3390/jcdd12020034
jcdd-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up †

by
Samuel Pintos-Rodríguez
1,2,
Víctor Alfonso Jiménez Díaz
1,2,
César Veiga
1,2,
Carlos Martínez García
1,2,
Francisco Caamaño Isorna
3,4,
Andrés Íñiguez Romo
1,5,6 and
Pablo Juan-Salvadores
1,2,*
1
Cardiovascular Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain
2
Cardiovascular Research Unit, Cardiology Department, Hospital Álvaro Cunqueiro, University Hospital of Vigo, 36312 Vigo, Spain
3
Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, IDIS University of Santiago de Compostela, 15706 Santiago de Compostela, Spain
4
CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
5
Cardiology Department, Complexo Hospitalario Universitario de Vigo (SERGAS), Álvaro Cunqueiro Hospital, 36312 Vigo, Spain
6
CIBER of Cardiovascular Disease (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
†
This article is a revised and expanded version of a paper in Rodriguez, S.P.; Salvadores, P.J.; Garcia, C.V.; González-Novoa, J.A.; Romo, A.I.; Díaz, V.A.J. TCT-775 Behind the Heart of Women: Coronary Artery Disease in Very Young Women. In Proceedings of the TCT® 2024: Transcatheter Cardiovascular Therapeutics, Washington, DC, USA, 27–30 November 2024.
J. Cardiovasc. Dev. Dis. 2025, 12(2), 34; https://doi.org/10.3390/jcdd12020034
Submission received: 9 December 2024 / Revised: 10 January 2025 / Accepted: 17 January 2025 / Published: 21 January 2025
(This article belongs to the Section Epidemiology, Lifestyle, and Cardiovascular Health)
Browse Figures
Versions Notes

Abstract

Coronary artery disease (CAD) is usually associated with the elderly, but an increase in its incidence has been recently reported among young people, including very young women. The aim of this study is to assess the associations between different clinical variables and the risk of early CAD and occurrence of major adverse cardiovascular events (MACEs) during follow-up. Our cohort consists of women ≤40 years referred for coronary angiography due to suspicion of CAD; a nested case–control study was conducted among these patients. In total, 19,321 coronary angiographies were performed between 2006 and 2015, of which 2.6% were in patients ≤40 years old; 52 women were finally included. Family history of CAD was strongly associated with the early onset of the disease [OR 5.94, 95%CI (1.13–31.15); p = 0.035] in young women. The incidence of MACE was also associated with depression [HR 8.20 95%CI (1.03–65.17); p = 0.047] and Castelli Index [HR 11.49, 95%CI (1.40–94.51); p = 0.023]. Primary prevention focused on genetic analysis for high-risk women with a family history of CAD and secondary prevention, targeting a better cholesterol management and mental health assistance must be considered.
Keywords: coronary artery disease; young women; percutaneous coronary intervention; Castelli index; depression; secondary prevention coronary artery disease; young women; percutaneous coronary intervention; Castelli index; depression; secondary prevention
Graphical Abstract

Share and Cite

MDPI and ACS Style

Pintos-Rodríguez, S.; Jiménez Díaz, V.A.; Veiga, C.; Martínez García, C.; Caamaño Isorna, F.; Íñiguez Romo, A.; Juan-Salvadores, P. Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up. J. Cardiovasc. Dev. Dis. 2025, 12, 34. https://doi.org/10.3390/jcdd12020034

AMA Style

Pintos-Rodríguez S, Jiménez Díaz VA, Veiga C, Martínez García C, Caamaño Isorna F, Íñiguez Romo A, Juan-Salvadores P. Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up. Journal of Cardiovascular Development and Disease. 2025; 12(2):34. https://doi.org/10.3390/jcdd12020034

Chicago/Turabian Style

Pintos-Rodríguez, Samuel, Víctor Alfonso Jiménez Díaz, César Veiga, Carlos Martínez García, Francisco Caamaño Isorna, Andrés Íñiguez Romo, and Pablo Juan-Salvadores. 2025. "Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up" Journal of Cardiovascular Development and Disease 12, no. 2: 34. https://doi.org/10.3390/jcdd12020034

APA Style

Pintos-Rodríguez, S., Jiménez Díaz, V. A., Veiga, C., Martínez García, C., Caamaño Isorna, F., Íñiguez Romo, A., & Juan-Salvadores, P. (2025). Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up. Journal of Cardiovascular Development and Disease, 12(2), 34. https://doi.org/10.3390/jcdd12020034

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop