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Inpatient Burden of Prurigo Nodularis in the United States
Open AccessCommunication

Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA
Author to whom correspondence should be addressed.
Medicines 2019, 6(4), 97;
Received: 1 August 2019 / Revised: 18 September 2019 / Accepted: 23 September 2019 / Published: 26 September 2019
(This article belongs to the Special Issue Pathogenesis and Treatment of Chronic Pruritus)
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted a systematic literature review to evaluate the clinical presentation, diagnosis, and etiologic factors of PN. In this review, we discuss common differential diagnoses of PN and recommend an evidence-based, standardized diagnostic evaluation for those with suspected PN. View Full-Text
Keywords: medical dermatology; prurigo nodularis; systematic review; itch; pruritus medical dermatology; prurigo nodularis; systematic review; itch; pruritus
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Kwon, C.D.; Khanna, R.; Williams, K.A.; Kwatra, M.M.; Kwatra, S.G. Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis. Medicines 2019, 6, 97.

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