Next Article in Journal
Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics
Next Article in Special Issue
Nanoemulsions of Essential Oils: New Tool for Control of Vector-Borne Diseases and In Vitro Effects on Some Parasitic Agents
Previous Article in Journal / Special Issue
Development and Validation of an HPLC-PDA Method for Biologically Active Quinonemethide Triterpenoids Isolated from Maytenus chiapensis
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle

Antiproliferative Activity of (-)-Rabdosiin Isolated from Ocimum sanctum L.

1
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece
2
Department of Biology, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece
*
Author to whom correspondence should be addressed.
Medicines 2019, 6(1), 37; https://doi.org/10.3390/medicines6010037
Received: 31 January 2019 / Revised: 5 March 2019 / Accepted: 7 March 2019 / Published: 12 March 2019
(This article belongs to the Special Issue Biological Potential and Medical Use of Secondary Metabolites)
  |  
PDF [1268 KB, uploaded 12 March 2019]
  |  

Abstract

Background: Ocimum sanctum L. (holy basil; Tulsi in Hindi) is an important medicinal plant, traditionally used in India. Methods: The phytochemical study of the nonpolar (dichloromethane 100%) and polar (methanol:water; 7:3) extracts yielded fourteen compounds. Compounds 6, 7, 9, 11, 12, and 13, along with the methanol:water extract were evaluated for their cytotoxicity against the human cancer cell lines MCF-7, SKBR3, and HCT-116, and normal peripheral blood mononuclear cells (PBMCs). Results: Five terpenoids, namely, ursolic acid (1), oleanolic acid (2), betulinic acid (3), stigmasterol (4), and β-caryophyllene oxide (5); two lignans, i.e., (-)-rabdosiin (6) and shimobashiric acid C (7); three flavonoids, luteolin (8), its 7-O-β-D-glucuronide (9), apigenin 7-O-β-D-glucuronide (10); and four phenolics, (E)-p-coumaroyl 4-O-β-D-glucoside (11), 3-(3,4-dihydroxyphenyl) lactic acid (12), protocatechuic acid (13), and vanillic acid (14) were isolated. Compound 6 was the most cytotoxic against the human cancer lines assessed and showed very low cytotoxicity against PBMCs. Conclusions: Based on these results, the structure of compound 6 shows some promise as a selective anticancer drug scaffold. View Full-Text
Keywords: Ocimum sanctum; Lamiaceae; (-)-rabdosiin; cytotoxic activity; triterpenoids; phenolic derivatives Ocimum sanctum; Lamiaceae; (-)-rabdosiin; cytotoxic activity; triterpenoids; phenolic derivatives
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Flegkas, A.; Milosević Ifantis, T.; Barda, C.; Samara, P.; Tsitsilonis, O.; Skaltsa, H. Antiproliferative Activity of (-)-Rabdosiin Isolated from Ocimum sanctum L.. Medicines 2019, 6, 37.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicines EISSN 2305-6320 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top