Antiproliferative Activity of (-)-Rabdosiin Isolated from Ocimum sanctum L.
AbstractBackground: Ocimum sanctum L. (holy basil; Tulsi in Hindi) is an important medicinal plant, traditionally used in India. Methods: The phytochemical study of the nonpolar (dichloromethane 100%) and polar (methanol:water; 7:3) extracts yielded fourteen compounds. Compounds 6, 7, 9, 11, 12, and 13, along with the methanol:water extract were evaluated for their cytotoxicity against the human cancer cell lines MCF-7, SKBR3, and HCT-116, and normal peripheral blood mononuclear cells (PBMCs). Results: Five terpenoids, namely, ursolic acid (1), oleanolic acid (2), betulinic acid (3), stigmasterol (4), and β-caryophyllene oxide (5); two lignans, i.e., (-)-rabdosiin (6) and shimobashiric acid C (7); three flavonoids, luteolin (8), its 7-O-β-D-glucuronide (9), apigenin 7-O-β-D-glucuronide (10); and four phenolics, (E)-p-coumaroyl 4-O-β-D-glucoside (11), 3-(3,4-dihydroxyphenyl) lactic acid (12), protocatechuic acid (13), and vanillic acid (14) were isolated. Compound 6 was the most cytotoxic against the human cancer lines assessed and showed very low cytotoxicity against PBMCs. Conclusions: Based on these results, the structure of compound 6 shows some promise as a selective anticancer drug scaffold. View Full-Text
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Flegkas, A.; Milosević Ifantis, T.; Barda, C.; Samara, P.; Tsitsilonis, O.; Skaltsa, H. Antiproliferative Activity of (-)-Rabdosiin Isolated from Ocimum sanctum L.. Medicines 2019, 6, 37.
Flegkas A, Milosević Ifantis T, Barda C, Samara P, Tsitsilonis O, Skaltsa H. Antiproliferative Activity of (-)-Rabdosiin Isolated from Ocimum sanctum L.. Medicines. 2019; 6(1):37.Chicago/Turabian Style
Flegkas, Alexandros; Milosević Ifantis, Tanja; Barda, Christina; Samara, Pinelopi; Tsitsilonis, Ourania; Skaltsa, Helen. 2019. "Antiproliferative Activity of (-)-Rabdosiin Isolated from Ocimum sanctum L.." Medicines 6, no. 1: 37.
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