Next Article in Journal
Transcranial Laser Stimulation Research—A New Helmet and First Data from Near Infrared Spectroscopy
Next Article in Special Issue
Scabiosa Genus: A Rich Source of Bioactive Metabolites
Previous Article in Journal
Acupuncture and Lifestyle Myopia in Primary School Children—Results from a Transcontinental Pilot Study Performed in Comparison to Moxibustion
Previous Article in Special Issue
The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessArticle
Medicines 2018, 5(3), 96;

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA
Author to whom correspondence should be addressed.
Received: 19 July 2018 / Revised: 24 August 2018 / Accepted: 28 August 2018 / Published: 31 August 2018
(This article belongs to the Special Issue Biological Potential and Medical Use of Secondary Metabolites)
Full-Text   |   PDF [7265 KB, uploaded 31 August 2018]   |  


Background: Frankincense, the oleo-gum resin of Boswellia trees, has been used in traditional medicine since ancient times. Frankincense has been used to treat wounds and skin infections, inflammatory diseases, dementia, and various other conditions. However, in many cases, the biomolecular targets for frankincense components are not well established. Methods: In this work, we have carried out a reverse docking study of Boswellia diterpenoids and triterpenoids with a library of 16034 potential druggable target proteins. Results: Boswellia diterpenoids showed selective docking to acetylcholinesterase, several bacterial target proteins, and HIV-1 reverse transcriptase. Boswellia triterpenoids targeted the cancer-relevant proteins (poly(ADP-ribose) polymerase-1, tankyrase, and folate receptor β), inflammation-relevant proteins (phospholipase A2, epoxide hydrolase, and fibroblast collagenase), and the diabetes target 11β-hydroxysteroid dehydrogenase. Conclusions: The preferential docking of Boswellia terpenoids is consistent with the traditional uses and the established biological activities of frankincense. View Full-Text
Keywords: frankincense; Boswellia; cembranoids; cneorubenoids; boswellic acids; molecular docking frankincense; Boswellia; cembranoids; cneorubenoids; boswellic acids; molecular docking

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Byler, K.G.; Setzer, W.N. Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins. Medicines 2018, 5, 96.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Medicines EISSN 2305-6320 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top