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Article

Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort

1
Center for Nutrition and Health Research, National Institute of Public Health (INSP), Cuernavaca 62100, Morelos, Mexico
2
National Council of Science and Technology (CONACyT), Mexico City 03940, Mexico
3
Center for Population Health Research, National Institute of Public Health (INSP), Cuernavaca 62100, Morelos, Mexico
4
Public Health Nutrition, School of Global Public Health, New York University, New York, NY 10012, USA
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Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City 11000, Mexico
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Department of Nutrition and Bio programming, National Institute of Perinatology, Mexico City 11000, Mexico
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Department of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, Mexico
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Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
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Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
*
Authors to whom correspondence should be addressed.
Toxics 2020, 8(4), 83; https://doi.org/10.3390/toxics8040083
Received: 21 August 2020 / Revised: 23 September 2020 / Accepted: 23 September 2020 / Published: 7 October 2020
(This article belongs to the Special Issue Toxic Metals, Chronic Diseases and Related Cancers)
Cadmium (Cd) is a toxic metal associated with adverse health effects, including kidney injury or disease. The aims of this study were to estimate dietary Cd exposure during childhood, and to evaluate the association of early-life dietary Cd with biomarkers of glomerular kidney function in 9-year-old Mexican children. Our study included 601 children from the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort with up to five follow-up food frequency questionnaires from 1 to 9 years of age; and 480 children with measures of serum creatinine, cystatin C, and blood nitrogen urea (BUN), as well as 9-year-old estimated glomerular filtration rate. Dietary Cd was estimated through food composition tables. Multiple linear regression models were used to analyze the association between 1 and 9 years, cumulative dietary Cd, and each kidney parameter. Dietary Cd exposure increased with age and exceeded the tolerable weekly intake (TWI = 2.5 µg/kg body weight) by 16–64% at all ages. Early-life dietary Cd exposure was above the TWI and we observed inverse associations between dietary Cd exposure and kidney function parameters. Additional studies are needed to assess kidney function trajectories through adolescence. Identifying preventable risk factors including environmental exposures in early life can contribute to decreasing the incidence of adult kidney disease. View Full-Text
Keywords: cadmium; children; diet; kidney function cadmium; children; diet; kidney function
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MDPI and ACS Style

Rodríguez-López, E.; Tamayo-Ortiz, M.; Ariza, A.C.; Ortiz-Panozo, E.; Deierlein, A.L.; Pantic, I.; Tolentino, M.C.; Estrada-Gutiérrez, G.; Parra-Hernández, S.; Espejel-Núñez, A.; Téllez-Rojo, M.M.; Wright, R.O.; Sanders, A.P. Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort. Toxics 2020, 8, 83. https://doi.org/10.3390/toxics8040083

AMA Style

Rodríguez-López E, Tamayo-Ortiz M, Ariza AC, Ortiz-Panozo E, Deierlein AL, Pantic I, Tolentino MC, Estrada-Gutiérrez G, Parra-Hernández S, Espejel-Núñez A, Téllez-Rojo MM, Wright RO, Sanders AP. Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort. Toxics. 2020; 8(4):83. https://doi.org/10.3390/toxics8040083

Chicago/Turabian Style

Rodríguez-López, Edna, Marcela Tamayo-Ortiz, Ana C. Ariza, Eduardo Ortiz-Panozo, Andrea L. Deierlein, Ivan Pantic, Mari C. Tolentino, Guadalupe Estrada-Gutiérrez, Sandra Parra-Hernández, Aurora Espejel-Núñez, Martha M. Téllez-Rojo, Robert O. Wright, and Alison P. Sanders 2020. "Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort" Toxics 8, no. 4: 83. https://doi.org/10.3390/toxics8040083

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