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Article

Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study

1
Department of Emergency Medicine, Taipei Veterans General Hospital Yu Li Branch, Hualien 981, Taiwan
2
Department of Emergency Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
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Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou branch, Taoyuan 333, Taiwan
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College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
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Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
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Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan
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National Defense Medical Center, Emergency Department, Taipei 114, Taiwan
*
Author to whom correspondence should be addressed.
Toxics 2020, 8(4), 84; https://doi.org/10.3390/toxics8040084
Received: 14 September 2020 / Revised: 2 October 2020 / Accepted: 7 October 2020 / Published: 10 October 2020
(This article belongs to the Special Issue Pesticides: An update of Exposure and Toxicity)
The efficacy of hemoperfusion (HP) in patients with acute paraquat poisoning (PQ) remains controversial. We conducted a multi-center retrospective study to include acute PQ-poisoned patients admitted to two tertiary medical centers between 2005 and 2015. We used the Severity Index of Paraquat Poisoning (SIPP) to stratify the severity of PQ-poisoned patients. The indication to start HP was a positive result for the semiquantitative urine PQ test and presentation to the hospital was within 24 h. Early HP was defined as the first session of HP performed within five hours of PQ ingestion. A total of 213 patients (100 HP group, 113 non-HP group) were eligible for the study. The overall 60-day mortality of poisoned patients was 75.6% (161/213). Multivariate Cox regression analysis showed no statistically significant difference in 60-day survival between HP and non-HP groups (95% confidence interval (CI): 0.84–1.63, p = 0.363). Further subgroup analysis in the HP group showed early HP (95% CI: 0.54–1.69, p = 0.880), and multiple secessions of HP (95% CI: 0.56–1.07, p = 0.124) were not significantly related to better survival. Among acute PQ-poisoned patients, this study found that HP was not associated with increased 60-day survival. Furthermore, neither early HP nor multiple secessions of HP were associated with survival. View Full-Text
Keywords: paraquat; intoxication; hemoperfusion paraquat; intoxication; hemoperfusion
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MDPI and ACS Style

Yeh, Y.-T.; Chen, C.-K.; Lin, C.-C.; Chang, C.-M.; Lan, K.-P.; How, C.-K.; Yen, H.-T.; Chen, Y.-C. Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study. Toxics 2020, 8, 84. https://doi.org/10.3390/toxics8040084

AMA Style

Yeh Y-T, Chen C-K, Lin C-C, Chang C-M, Lan K-P, How C-K, Yen H-T, Chen Y-C. Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study. Toxics. 2020; 8(4):84. https://doi.org/10.3390/toxics8040084

Chicago/Turabian Style

Yeh, Ying-Tse, Chun-Kuei Chen, Chih-Chuan Lin, Chia-Ming Chang, Kai-Ping Lan, Chorng-Kuang How, Hung-Tsang Yen, and Yen-Chia Chen. 2020. "Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study" Toxics 8, no. 4: 84. https://doi.org/10.3390/toxics8040084

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