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Toxics 2018, 6(4), 69; https://doi.org/10.3390/toxics6040069

Optimization of Sample Preparation for Detection of 10 Phthalates in Non-Alcoholic Beverages in Northern Vietnam

1
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam
2
University of Science, Vietnam National University HCMC, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 720400, Vietnam
*
Author to whom correspondence should be addressed.
Received: 30 October 2018 / Revised: 11 November 2018 / Accepted: 15 November 2018 / Published: 19 November 2018
(This article belongs to the Special Issue Analysis of Chemical Contaminants in Food)
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Abstract

A novel method was developed for the sensitive, cheap and fast quantitation of 10 phthalates in non-alcoholic beverages by liquid–liquid extraction (LLE) combined with gas chromatography tandem mass spectrometry (GC-MS/MS). The best results were obtained when n-hexane was used as extraction solvent. A central composite design (CCD) was applied to select the most appreciated operating condition. The method performance was evaluated according to the SANTE/11945/2015 guidelines and was linear in the 0.1 to 200 µg/L range for 10 phthalate compounds, with r2 > 0.996 and individual residuals <15%. Repeatability (RSDr), within-laboratory reproducibility (RSDwr), and the trueness range were from 2.7 to 9.1%, from 3.4 to 14.3% and from 91.5 to 118.1%, respectively. The limit of detection (LOD) was between 0.5 to 1.0 ng/L and the limit of quantitation (LOQ) was between 1.5 to 3.0 ng/L for all 10 compounds. The developed method was successfully applied to the analysis of non-alcoholic beverages. View Full-Text
Keywords: phthalate; non-alcoholic beverages; liquid–liquid extraction; response surface methodology; GC-MS/MS phthalate; non-alcoholic beverages; liquid–liquid extraction; response surface methodology; GC-MS/MS
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Tran-Lam, T.-T.; Dao, Y.H.; Nguyen, D.T.; Ma, H.K.; Pham, T.Q.; Le, G.T. Optimization of Sample Preparation for Detection of 10 Phthalates in Non-Alcoholic Beverages in Northern Vietnam. Toxics 2018, 6, 69.

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