Next Article in Journal / Special Issue
Methylmercury Exposure and Developmental Outcomes in Tohoku Study of Child Development at 18 Months of Age
Previous Article in Journal / Special Issue
Oxidative Stress in Methylmercury-Induced Cell Toxicity
Article Menu

Export Article

Open AccessFeature PaperArticle
Toxics 2018, 6(3), 48; https://doi.org/10.3390/toxics6030048

Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression

1
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan
2
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan
3
Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea
4
Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan
5
Faculty of Health and Medical Care, Hachinohe Gakuin University, 3-98 Mihono, Hachinohe 031-8588, Japan
*
Author to whom correspondence should be addressed.
Received: 15 June 2018 / Revised: 2 August 2018 / Accepted: 7 August 2018 / Published: 12 August 2018
(This article belongs to the Special Issue Mercury and Methylmercury Toxicology and Risk Assessment)
Full-Text   |   PDF [2406 KB, uploaded 13 August 2018]   |  

Abstract

Mercury compounds are known to cause central nervous system disorders; however the detailed molecular mechanisms of their actions remain unclear. Methylmercury increases the expression of several chemokine genes, specifically in the brain, while metallothionein-III (MT-III) has a protective role against various brain diseases. In this study, we investigated the involvement of MT-III in chemokine gene expression changes in response to methylmercury and mercury vapor in the cerebrum and cerebellum of wild-type mice and MT-III null mice. No difference in mercury concentration was observed between the wild-type mice and MT-III null mice in any brain tissue examined. The expression of Ccl3 in the cerebrum and of Cxcl10 in the cerebellum was increased by methylmercury in the MT-III null but not the wild-type mice. The expression of Ccl7 in the cerebellum was increased by mercury vapor in the MT-III null mice but not the wild-type mice. However, the expression of Ccl12 and Cxcl12 was increased in the cerebrum by methylmercury only in the wild-type mice and the expression of Ccl3 in the cerebellum was increased by mercury vapor only in the wild-type mice. These results indicate that MT-III does not affect mercury accumulation in the brain, but that it affects the expression of some chemokine genes in response to mercury compounds. View Full-Text
Keywords: methylmercury; mercury vapor; metallothionein-III; chemokine methylmercury; mercury vapor; metallothionein-III; chemokine
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Lee, J.-Y.; Tokumoto, M.; Hwang, G.-W.; Kim, M.-S.; Takahashi, T.; Naganuma, A.; Yoshida, M.; Satoh, M. Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression. Toxics 2018, 6, 48.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxics EISSN 2305-6304 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top