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Volume 11
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10.3390/foods11010098
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Article

The Main Anthocyanin Monomer from Lycium ruthenicum Murray Fruit Mediates Obesity via Modulating the Gut Microbiota and Improving the Intestinal Barrier

by
Peiyun Liu
1,
Wangting Zhou
1,
Weiqi Xu
1,
Yujia Peng
1,
Yamei Yan
2,3,
Lu Lu
2,3,
Jia Mi
2,3,
Xiaoxiong Zeng
1,* and
Youlong Cao
2,3,*
1
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
2
Institute of Wolfberry Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China
3
National Wolfberry Engineering Research Center, Yinchuan 750002, China
*
Authors to whom correspondence should be addressed.
Foods 2022, 11(1), 98; https://doi.org/10.3390/foods11010098
Submission received: 18 November 2021 / Revised: 23 December 2021 / Accepted: 27 December 2021 / Published: 30 December 2021
(This article belongs to the Section Food Nutrition)
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Abstract

Anthocyanins have been shown to exert certain antiobesity properties, but the specific relationship between anthocyanin-induced beneficial effects and the gut microbiota remains unclear. Petunidin-3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside) (P3G) is the main anthocyanin monomer from the fruit of Lycium ruthenicum Murray. Therefore, in this study, we investigated the antiobesity and remodeling effects of P3G on gut microbiota through a high-fat diet (HFD)-induced obesity mouse model and a fecal microbiota transplantation experiment. P3G was found to reduce body weight gain, fat accumulation, and liver steatosis in HFD-induced obese mice. Moreover, supplementation with P3G alleviated the HFD-induced imbalance in gut microbiota composition, and transferring the P3G-regulated gut microbiota to recipient mice provided comparable protection against obesity. This is the first time evidence is provided that P3G has an antiobesity effect by changing the intestinal microbiota. Our present data highlight a link between P3G intervention and enhancement in gut barrier integrity. This may be a promising option for obesity prevention.
Keywords: Lycium ruthenicum Murray; anthocyanins; obesity; gut microbiota; intestinal barrier Lycium ruthenicum Murray; anthocyanins; obesity; gut microbiota; intestinal barrier

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MDPI and ACS Style

Liu, P.; Zhou, W.; Xu, W.; Peng, Y.; Yan, Y.; Lu, L.; Mi, J.; Zeng, X.; Cao, Y. The Main Anthocyanin Monomer from Lycium ruthenicum Murray Fruit Mediates Obesity via Modulating the Gut Microbiota and Improving the Intestinal Barrier. Foods 2022, 11, 98. https://doi.org/10.3390/foods11010098

AMA Style

Liu P, Zhou W, Xu W, Peng Y, Yan Y, Lu L, Mi J, Zeng X, Cao Y. The Main Anthocyanin Monomer from Lycium ruthenicum Murray Fruit Mediates Obesity via Modulating the Gut Microbiota and Improving the Intestinal Barrier. Foods. 2022; 11(1):98. https://doi.org/10.3390/foods11010098

Chicago/Turabian Style

Liu, Peiyun, Wangting Zhou, Weiqi Xu, Yujia Peng, Yamei Yan, Lu Lu, Jia Mi, Xiaoxiong Zeng, and Youlong Cao. 2022. "The Main Anthocyanin Monomer from Lycium ruthenicum Murray Fruit Mediates Obesity via Modulating the Gut Microbiota and Improving the Intestinal Barrier" Foods 11, no. 1: 98. https://doi.org/10.3390/foods11010098

APA Style

Liu, P., Zhou, W., Xu, W., Peng, Y., Yan, Y., Lu, L., Mi, J., Zeng, X., & Cao, Y. (2022). The Main Anthocyanin Monomer from Lycium ruthenicum Murray Fruit Mediates Obesity via Modulating the Gut Microbiota and Improving the Intestinal Barrier. Foods, 11(1), 98. https://doi.org/10.3390/foods11010098

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