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Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review

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Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland
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Department of Oral Surgery, Faculty of Medicine, Jagiellonian University Medical College, 4 Montelupich Str., 31-155 Kraków, Poland
3
Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Danijela Bursać Kovačević and Predrag Putnik
Foods 2021, 10(4), 720; https://doi.org/10.3390/foods10040720
Received: 19 February 2021 / Revised: 23 March 2021 / Accepted: 26 March 2021 / Published: 29 March 2021
(This article belongs to the Special Issue Sustainable Functional Food Processing)
Bisphosphonates and selective estrogen receptor modulators (SERMs) represent the two most important groups of medications taken orally and employed in osteoporosis treatment. Effectiveness of the therapy may be affected by poor patient adherence, in particular, due to the inconvenient dosing regimen of oral bisphosphonates. With this review we aimed to assess the effects that food, beverages, and dietary supplements consumed during treatment, along with the dosing regimens, may have on pharmacokinetics and pharmacodynamics of oral drugs employed in treating osteoporosis; we also aimed to shape the recommendations valuable for professional patients’ counseling and education, to provide appropriate dosing regimens in order to improve adherence to the therapy. Food, beverages such as coffee, juices, and mineral water, as well as dietary supplements containing multivalent cations, e.g., calcium, magnesium, aluminium, iron, showed to have a deleterious effect on the bioavailability of all the investigated oral bisphosphonates, specifically alendronate, risedronate, ibandronate, minodronate, and etidronate. For risedronate, a delayed-release (DR) tablet was designed to solve the malabsorption problem in the presence of food, hence DR risedronate can be ingested following breakfast. For other oral bisphosphonates, the proper interval between drug and food, beverages, and dietary supplements intake should be maintained to minimize the risk of interactions. The effect of food on pharmacokinetic parameters of selective estrogen receptor modulators (SERMs) was found to be clinically irrelevant. View Full-Text
Keywords: bisphosphonates; SERMs; interaction; food; supplements; bioavailability; meal; coffee; juice; mineral water bisphosphonates; SERMs; interaction; food; supplements; bioavailability; meal; coffee; juice; mineral water
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MDPI and ACS Style

Wiesner, A.; Szuta, M.; Galanty, A.; Paśko, P. Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review. Foods 2021, 10, 720. https://doi.org/10.3390/foods10040720

AMA Style

Wiesner A, Szuta M, Galanty A, Paśko P. Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review. Foods. 2021; 10(4):720. https://doi.org/10.3390/foods10040720

Chicago/Turabian Style

Wiesner, Agnieszka, Mariusz Szuta, Agnieszka Galanty, and Paweł Paśko. 2021. "Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review" Foods 10, no. 4: 720. https://doi.org/10.3390/foods10040720

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