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Targeted Contrast Agents for Molecular MRI

Centre de Biophysique Moléculaire, Rue Charles Sadron, 45071 Orléans CEDEX 2, France
Inorganics 2018, 6(4), 129;
Received: 8 November 2018 / Revised: 27 November 2018 / Accepted: 30 November 2018 / Published: 4 December 2018
(This article belongs to the Special Issue MRI Contrast Agents)
Molecular magnetic resonance imaging (MRI) provides information non-invasively at cellular and molecular levels, for both early diagnosis and monitoring therapeutic follow-up. This imaging technique requires the development of a new class of contrast agents, which signal changes (typically becomes enhanced) when in presence of the cellular or molecular process to be evaluated. Even if molecular MRI has had a prominent role in the advances in medicine over the past two decades, the large majority of the developed probes to date are still in preclinical level, or eventually in phase I or II clinical trials. The development of novel imaging probes is an emergent active research domain. This review focuses on gadolinium-based specific-targeted contrast agents, providing rational design considerations and examples of the strategies recently reported in the literature. View Full-Text
Keywords: MRI; molecular imaging; targeted contrast agent; lanthanide; protein-based contrast agent MRI; molecular imaging; targeted contrast agent; lanthanide; protein-based contrast agent
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MDPI and ACS Style

Lacerda, S. Targeted Contrast Agents for Molecular MRI. Inorganics 2018, 6, 129.

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