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Inorganics 2018, 6(4), 129; https://doi.org/10.3390/inorganics6040129

Targeted Contrast Agents for Molecular MRI

Centre de Biophysique Moléculaire, Rue Charles Sadron, 45071 Orléans CEDEX 2, France
Received: 8 November 2018 / Revised: 27 November 2018 / Accepted: 30 November 2018 / Published: 4 December 2018
(This article belongs to the Special Issue MRI Contrast Agents)
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Abstract

Molecular magnetic resonance imaging (MRI) provides information non-invasively at cellular and molecular levels, for both early diagnosis and monitoring therapeutic follow-up. This imaging technique requires the development of a new class of contrast agents, which signal changes (typically becomes enhanced) when in presence of the cellular or molecular process to be evaluated. Even if molecular MRI has had a prominent role in the advances in medicine over the past two decades, the large majority of the developed probes to date are still in preclinical level, or eventually in phase I or II clinical trials. The development of novel imaging probes is an emergent active research domain. This review focuses on gadolinium-based specific-targeted contrast agents, providing rational design considerations and examples of the strategies recently reported in the literature. View Full-Text
Keywords: MRI; molecular imaging; targeted contrast agent; lanthanide; protein-based contrast agent MRI; molecular imaging; targeted contrast agent; lanthanide; protein-based contrast agent
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lacerda, S. Targeted Contrast Agents for Molecular MRI. Inorganics 2018, 6, 129.

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