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Inorganics
Volume 14
Issue 8
10.3390/inorganics14080200
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Review

A Recent Review of the Therapeutic Potential of Gold, Platinum, and Ruthenium Complexes Combined with Certain Organic Compounds

by
Petya Marinova
1,
Miroslava Strandzheva
1,
Denica Blazheva
2,
Ionut Iulian Lungu
3,*,
Oana Cioanca
3,
Monica Hancianu
3 and
Alina Stefanache
3
1
Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv, “Tzar Assen” Str. 24, 4000 Plovdiv, Bulgaria
2
Department of Microbiology and Biotechnology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria
3
Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania
*
Author to whom correspondence should be addressed.
Inorganics 2026, 14(8), 200; https://doi.org/10.3390/inorganics14080200
Submission received: 8 June 2026 / Revised: 24 July 2026 / Accepted: 24 July 2026 / Published: 27 July 2026
(This article belongs to the Special Issue Metal Complexes Containing Bioactive Ligands: Structure and Biological Evaluation, 2nd Edition)
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Abstract

The synthesis and systematic investigation of inorganic and organic compounds are fundamental to medicinal and pharmaceutical chemistry, particularly for developing novel therapeutic agents. Transition-metal complexes and bioactive organic compounds have shown significant potential to modulate cellular pathways, yielding anticancer, antimicrobial, and anti-inflammatory effects. This review summarizes recent advances in the synthesis, structural characterization, and therapeutic evaluation of gold (Au), platinum (Pt), and ruthenium (Ru) complexes, as well as selected organic compounds, with an emphasis on their biological activities and potential clinical relevance. The integration of synthetic chemistry with biological evaluation underscores the therapeutic potential of gold (Au), platinum (Pt), and ruthenium (Ru) complexes, as well as organic compounds. Au(I/III), Pt(II/IV), and Ru(II/III) complexes demonstrated notable in vivo anticancer activity, while selected organic derivatives exhibited promising bioactive properties. This review aims to support researchers and clinicians in the ongoing development of novel compounds with clinical relevance for anticancer, antimicrobial, and anti-inflammatory applications.
Keywords: complexes; gold; platinum; ruthenium; anticancer; antimicrobial properties complexes; gold; platinum; ruthenium; anticancer; antimicrobial properties

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MDPI and ACS Style

Marinova, P.; Strandzheva, M.; Blazheva, D.; Lungu, I.I.; Cioanca, O.; Hancianu, M.; Stefanache, A. A Recent Review of the Therapeutic Potential of Gold, Platinum, and Ruthenium Complexes Combined with Certain Organic Compounds. Inorganics 2026, 14, 200. https://doi.org/10.3390/inorganics14080200

AMA Style

Marinova P, Strandzheva M, Blazheva D, Lungu II, Cioanca O, Hancianu M, Stefanache A. A Recent Review of the Therapeutic Potential of Gold, Platinum, and Ruthenium Complexes Combined with Certain Organic Compounds. Inorganics. 2026; 14(8):200. https://doi.org/10.3390/inorganics14080200

Chicago/Turabian Style

Marinova, Petya, Miroslava Strandzheva, Denica Blazheva, Ionut Iulian Lungu, Oana Cioanca, Monica Hancianu, and Alina Stefanache. 2026. "A Recent Review of the Therapeutic Potential of Gold, Platinum, and Ruthenium Complexes Combined with Certain Organic Compounds" Inorganics 14, no. 8: 200. https://doi.org/10.3390/inorganics14080200

APA Style

Marinova, P., Strandzheva, M., Blazheva, D., Lungu, I. I., Cioanca, O., Hancianu, M., & Stefanache, A. (2026). A Recent Review of the Therapeutic Potential of Gold, Platinum, and Ruthenium Complexes Combined with Certain Organic Compounds. Inorganics, 14(8), 200. https://doi.org/10.3390/inorganics14080200

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