Synthesis, Structural Characterization, Cytotoxicity, and Antibacterial Properties of Gold(III) Complexes with Hydrazones Derived from Vitamin B₆

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

While the chemistry of gold(I) complexes is currently quite well understood, gold(III) chemistry offers enormous potential for the discovery of entirely new compounds, chemical phenomena, and so on. The manuscript by Gamov et al. addresses precisely this topic. The structure of the work is readable, and the research methodology employed is adequate. However, the manuscript requires some corrections before publication. In particular:

Page 2, lines 43-35
This statement should be supported by appropriate examples from the literature.

The NMR spectra in Figs. 2 and 3 should be moved to the Supplementary Material.

The electronic nature of gold(III) complexes with nitrogen-containing organic compounds has recently been described and characterized [Chemistry of Heterocyclic Compounds, 60, 639 (2024)]. This should be mentioned in the text.

Were the microbiological studies supported by molecular modeling data? This is not essential, but if the authors have such data, it is worth including it.

Author Response

Please, find the response in the attached file.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The article under the title “Synthesis, Structural Characterization, and Antibacterial Properties of Gold(III) Complexes with Hydrazones Derived from Vitamin B6” by Petrova and coworkers presents results synthesis, structure and biological activity of several novel goldl(III)-hydrazone complexes. The authors have presented these results well with the inclusion of complete spectroscopic characterization. The article could be of potential interest to the readers of the Inorganics, although there are some points that should be addressed before the final decision. Therefore, my recommendation is MAJOR REVISION.

 

The authors should answer the following:

1. “in short supply” is not an appropriate term, it should be changed
2. The authors should mention if complexes between B6-containing hydrazones have been described in literature.
3. The NMR chemical characterization of the complexes should be improved and more details should be given, for example how the structure of hydrazone affects the shift in the NMR spectra of pure ligands and complexes. As the authors mention that the redistribution of electron density occurs, the structure of ligand should influence this process.
4. The authors mentioned mass spectrometry in the abstract, how the experimental results compare with the theoretical values of mass?
5. Again, how does the structure of ligands affect the shifts in the IR spectrum?
6. The authors should discuss the results from Table 1 in the main text, as only the values are presented without any discussion. The results should be compared to the literature data for similar ligands or metal.
7. The authors have performed a linear fit using the calculated properties, some of the limitations of this methodology should be given.
8. The authors should compare the antibacterial activity of these complexes to the literature data and give a rationale why where these compounds examined for antibacterial activity in the first place.
9. What were the expected results for the mixtures in the last section? The authors should present some of the major quantitative data in the main text, as the discussion does not include the actual numbers.
10. More of the quantitative data should be given in the conclusion to support it.

Author Response

Please, find the response in the attached file.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

The authors have answered all of the questions properly. The manuscript can be accepted in the present form. 

Author Response

Thanks a lot for your positive feedback. We aprreciate your time and your efforts focused on helping us to improve our contribution.