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Photonics
Volume 8
Issue 10
10.3390/photonics8100444
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Article

Proposal for a Skin Layer-Wise Decomposition Model of Spatially-Resolved Diffuse Reflectance Spectra Based on Maximum Depth Photon Distributions: A Numerical Study

by
Victor Colas
1,*,
Walter Blondel
1,
Grégoire Khairallah
1,2,
Christian Daul
1 and
Marine Amouroux
1
1
CRAN, BioSiS Department, Université de Lorraine-CNRS, F-54000 Nancy, France
2
Department of Plastic, Aesthetic and Reconstructive Surgery, Metz-Thionville Regional Hospital, F-57530 Ars-Laquenexy, France
*
Author to whom correspondence should be addressed.
Photonics 2021, 8(10), 444; https://doi.org/10.3390/photonics8100444
Submission received: 27 August 2021 / Revised: 25 September 2021 / Accepted: 12 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Tissue Optics)
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Abstract

In the context of cutaneous carcinoma diagnosis based on in vivo optical biopsy, Diffuse Reflectance (DR) spectra, acquired using a Spatially Resolved (SR) sensor configuration, can be analyzed to distinguish healthy from pathological tissues. The present contribution aims at studying the depth distribution of SR-DR-detected photons in skin from the perspective of analyzing how these photons contribute to acquired spectra carrying local physiological and morphological information. Simulations based on modified Cuda Monte Carlo Modeling of Light transport were performed on a five-layer human skin optical model with epidermal thickness, phototype and dermal blood content as variable parameters using (i) wavelength-resolved scattering and absorption properties and (ii) the geometrical configuration of a multi-optical fiber probe implemented on an SR-DR spectroscopic device currently used in clinics. Through histograms of the maximum probed depth and their exploitation, we provide numerical evidence linking the characteristic penetration depth of the detected photons to their wavelengths and four source–sensor distances, which made it possible to propose a decomposition of the DR signals related to skin layer contributions.
Keywords: Diffuse Reflectance Spectroscopy; probed depth; skin layer; Monte Carlo Simulation; skin optics Diffuse Reflectance Spectroscopy; probed depth; skin layer; Monte Carlo Simulation; skin optics

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MDPI and ACS Style

Colas, V.; Blondel, W.; Khairallah, G.; Daul, C.; Amouroux, M. Proposal for a Skin Layer-Wise Decomposition Model of Spatially-Resolved Diffuse Reflectance Spectra Based on Maximum Depth Photon Distributions: A Numerical Study. Photonics 2021, 8, 444. https://doi.org/10.3390/photonics8100444

AMA Style

Colas V, Blondel W, Khairallah G, Daul C, Amouroux M. Proposal for a Skin Layer-Wise Decomposition Model of Spatially-Resolved Diffuse Reflectance Spectra Based on Maximum Depth Photon Distributions: A Numerical Study. Photonics. 2021; 8(10):444. https://doi.org/10.3390/photonics8100444

Chicago/Turabian Style

Colas, Victor, Walter Blondel, Grégoire Khairallah, Christian Daul, and Marine Amouroux. 2021. "Proposal for a Skin Layer-Wise Decomposition Model of Spatially-Resolved Diffuse Reflectance Spectra Based on Maximum Depth Photon Distributions: A Numerical Study" Photonics 8, no. 10: 444. https://doi.org/10.3390/photonics8100444

APA Style

Colas, V., Blondel, W., Khairallah, G., Daul, C., & Amouroux, M. (2021). Proposal for a Skin Layer-Wise Decomposition Model of Spatially-Resolved Diffuse Reflectance Spectra Based on Maximum Depth Photon Distributions: A Numerical Study. Photonics, 8(10), 444. https://doi.org/10.3390/photonics8100444

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