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Open AccessArticle

Quantitative Analysis of 4 × 4 Mueller Matrix Transformation Parameters for Biomedical Imaging

by Wei Sheng 1,2,†, Weipeng Li 1,2,†, Ji Qi 3,4, Teng Liu 1,5, Honghui He 1,*, Yang Dong 1,2, Shaoxiong Liu 6, Jian Wu 1, Daniel S. Elson 3,4,* and Hui Ma 1,5,7,*
1
Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
2
Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
3
Hamlyn Centre for Robotic Surgery, Institute of Global Health Innovation, Imperial College London, Exhibition Road, London SW7 2AZ, UK
4
Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK
5
Department of Physics, Tsinghua University, Beijing 100084, China
6
Shenzhen Sixth People’s Hospital (Nanshan Hospital) Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518052, China
7
Center for Precision Medicine and Healthcare, Tsinghua-Berkeley Shenzhen Institute, Shenzhen 518071, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Photonics 2019, 6(1), 34; https://doi.org/10.3390/photonics6010034
Received: 28 February 2019 / Revised: 14 March 2019 / Accepted: 19 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Biomedical Photonics Advances)
Mueller matrix polarimetry is a potentially powerful technique for obtaining microstructural information of biomedical specimens. Thus, it has found increasing application in both backscattering imaging of bulk tissue samples and transmission microscopic imaging of thin tissue slices. Recently, we proposed a technique to transform the 4 × 4 Mueller matrix elements into a group of parameters, which have explicit associations with specific microstructural features of samples. In this paper, we thoroughly analyze the relationships between the Mueller matrix transformation parameters and the characteristic microstructures of tissues by using experimental phantoms and Monte Carlo simulations based on different tissue mimicking models. We also adopt quantitative evaluation indicators to compare the Mueller matrix transformation parameters with the Mueller matrix polar decomposition parameters. The preliminary imaging results of bulk porcine colon tissues and thin human pathological tissue slices demonstrate the potential of Mueller matrix transformation parameters as biomedical diagnostic indicators. Also, this study provides quantitative criteria for parameter selection in biomedical Mueller matrix imaging. View Full-Text
Keywords: Mueller matrix; cylindrical scatterers; birefringence; biomedical imaging; quantitative criteria Mueller matrix; cylindrical scatterers; birefringence; biomedical imaging; quantitative criteria
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Sheng, W.; Li, W.; Qi, J.; Liu, T.; He, H.; Dong, Y.; Liu, S.; Wu, J.; Elson, D.S.; Ma, H. Quantitative Analysis of 4 × 4 Mueller Matrix Transformation Parameters for Biomedical Imaging. Photonics 2019, 6, 34.

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