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A Novel Hexahedron Photonic Crystal Fiber in Terahertz Propagation: Design and Analysis
Open AccessArticle

Verification of Non-thermal Effects of 0.3–0.6 THz-Waves on Human Cultured Cells

1
RIKEN, Center for Advanced Photonics, Sendai 980-0845, Japan
2
Terahertz technology research Center, National Institute of Information and Communications Technology, Koganei 184-8795, Japan
3
Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan
*
Author to whom correspondence should be addressed.
Photonics 2019, 6(1), 33; https://doi.org/10.3390/photonics6010033
Received: 30 January 2019 / Revised: 20 March 2019 / Accepted: 21 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Terahertz Photonics)
Recent progress has been made in the development of terahertz (THz) waves for practical applications. Few studies that have assessed the biological effects of THz waves have been reported, and the data currently available regarding the safety of THz waves is inadequate. In this study, the effect of THz wave exposure on two cultured cells was assessed using a widely tunable THz source with a 0.3–0.6 THz frequency range, which can be used and increased in one GHz increments. The THz waves applied to the cultured cells were weak enough such that any thermal effects could be disregarded. The influence of THz wave exposure on both the proliferative and metabolic activities of these cells was investigated, as well as the extent of the thermal stress placed on the cells. In this work, no measurable effect on the proliferative or metabolic activities of either cell type was observed following the exposure to THz waves. No differences in the quantity of cDNA related to heat shock protein 70 was detected in either the sham or exposure group. As such, no differences in cellular activity between cells exposed to THz waves and those not exposed were observed. View Full-Text
Keywords: Terahertz (THz); non-thermal effect; long-term exposure; 1-GHz frequency steps; widely tunable source; human cultured cells Terahertz (THz); non-thermal effect; long-term exposure; 1-GHz frequency steps; widely tunable source; human cultured cells
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Yaekashiwa, N.; Yoshida, H.; Otsuki, S.; Hayashi, S.; Kawase, K. Verification of Non-thermal Effects of 0.3–0.6 THz-Waves on Human Cultured Cells. Photonics 2019, 6, 33.

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