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Children
Volume 12
Issue 5
10.3390/children12050647
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Fertility Preservation in Female Children and Adolescent Cancer Patients

by
Min Wang
and
Chao Yang
*
Department of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
*
Author to whom correspondence should be addressed.
Children 2025, 12(5), 647; https://doi.org/10.3390/children12050647 (registering DOI)
Submission received: 7 April 2025 / Revised: 9 May 2025 / Accepted: 13 May 2025 / Published: 16 May 2025
(This article belongs to the Section Pediatric Hematology & Oncology)
Versions Notes

Abstract

The five-year survival rate for childhood cancer now exceeds 80%, leading to an increasing number of young women who may confront infertility in the future due to the gonadotoxic effects of surgery, chemotherapy, and radiation. Despite current guidelines advocating for fertility preservation counseling and necessary reproductive protection measures for all patients, significant barriers and ethical considerations persist, particularly within the pediatric and adolescent female population. In this review, we provide an overview of the impact and mechanisms of anti-tumor therapies on ovarian function, fertility preservation strategies for pediatric and adolescent patients, and the associated costs and ethical considerations that need to be addressed.
Keywords: fertility preservation; cancer; pediatric; adolescent; female fertility preservation; cancer; pediatric; adolescent; female

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MDPI and ACS Style

Wang, M.; Yang, C. Fertility Preservation in Female Children and Adolescent Cancer Patients. Children 2025, 12, 647. https://doi.org/10.3390/children12050647

AMA Style

Wang M, Yang C. Fertility Preservation in Female Children and Adolescent Cancer Patients. Children. 2025; 12(5):647. https://doi.org/10.3390/children12050647

Chicago/Turabian Style

Wang, Min, and Chao Yang. 2025. "Fertility Preservation in Female Children and Adolescent Cancer Patients" Children 12, no. 5: 647. https://doi.org/10.3390/children12050647

APA Style

Wang, M., & Yang, C. (2025). Fertility Preservation in Female Children and Adolescent Cancer Patients. Children, 12(5), 647. https://doi.org/10.3390/children12050647

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