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Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies

Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ 85054, USA
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Biomedicines 2019, 7(1), 17; https://doi.org/10.3390/biomedicines7010017
Received: 28 January 2019 / Revised: 4 March 2019 / Accepted: 9 March 2019 / Published: 10 March 2019
(This article belongs to the Special Issue Stem Cells and Cancer Therapeutics)
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Abstract

Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies. View Full-Text
Keywords: cancer stem cell; BBI-608; napabucasin; STAT3; pancreatic cancer; gastric cancer; colorectal cancer; Wnt/β-catenin cancer stem cell; BBI-608; napabucasin; STAT3; pancreatic cancer; gastric cancer; colorectal cancer; Wnt/β-catenin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sonbol, M.B.; Ahn, D.H.; Bekaii-Saab, T. Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies. Biomedicines 2019, 7, 17.

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