Next Article in Journal / Special Issue
Penicillin Allergy Assessment and Skin Testing in the Outpatient Setting
Previous Article in Journal
The Use of Primary Care Electronic Health Records for Research: Lipid Medications and Mortality in Elderly Patients
Previous Article in Special Issue
Sulfonamide Allergies
Review

Macrolide Allergic Reactions

1
Department of Pharmacotherapeutics and Clinical Research, University of South Florida College of Pharmacy, Tampa, FL 33612, USA
2
Department of Pharmacy Practice, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL 33416, USA
3
Department of Pharmaceutical Sciences, University of South Florida College of Pharmacy, Tampa, FL 33612, USA
4
Department of Clinical Sciences, Ben and Maytee Fisch College of Pharmacy, University of Texas at Tyler, Tyler, TX 75799, USA
*
Author to whom correspondence should be addressed.
The authors contributed equally to the present work.
Pharmacy 2019, 7(3), 135; https://doi.org/10.3390/pharmacy7030135
Received: 2 August 2019 / Revised: 7 September 2019 / Accepted: 11 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Antibiotic Allergies)
Macrolides are antimicrobial agents that can be used to treat a variety of infections. Allergic reactions to macrolides occur infrequently but can include minor to severe cutaneous reactions as well as systemic life-threatening reactions such as anaphylaxis. Most reports of allergic reactions occurred in patients without prior exposure to a macrolide. Cross-reactivity among macrolides may occur due to the similarities in their chemical structures; however, some published literature indicates that some patients can tolerate a different macrolide. Most published reports detailed an allergic reaction to erythromycin. Desensitization protocols to clarithromycin and azithromycin have been described in the literature. The purpose of this article is to summarize macrolide-associated allergic reactions reported in published literature. An extensive literature search was conducted to identify publications linking macrolides to hypersensitivity reactions. View Full-Text
Keywords: macrolides; allergy; azithromycin; erythromycin; clarithromycin; fidaxomicin; desensitization macrolides; allergy; azithromycin; erythromycin; clarithromycin; fidaxomicin; desensitization
Show Figures

Figure 1

MDPI and ACS Style

Shaeer, K.M.; Chahine, E.B.; Varghese Gupta, S.; Cho, J.C. Macrolide Allergic Reactions. Pharmacy 2019, 7, 135. https://doi.org/10.3390/pharmacy7030135

AMA Style

Shaeer KM, Chahine EB, Varghese Gupta S, Cho JC. Macrolide Allergic Reactions. Pharmacy. 2019; 7(3):135. https://doi.org/10.3390/pharmacy7030135

Chicago/Turabian Style

Shaeer, Kristy M., Elias B. Chahine, Sheeba Varghese Gupta, and Jonathan C. Cho. 2019. "Macrolide Allergic Reactions" Pharmacy 7, no. 3: 135. https://doi.org/10.3390/pharmacy7030135

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop