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Sulfonamide Allergies

Macrolide Allergic Reactions

Department of Pharmacotherapeutics and Clinical Research, University of South Florida College of Pharmacy, Tampa, FL 33612, USA
Department of Pharmacy Practice, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL 33416, USA
Department of Pharmaceutical Sciences, University of South Florida College of Pharmacy, Tampa, FL 33612, USA
Department of Clinical Sciences, Ben and Maytee Fisch College of Pharmacy, University of Texas at Tyler, Tyler, TX 75799, USA
Author to whom correspondence should be addressed.
The authors contributed equally to the present work.
Pharmacy 2019, 7(3), 135;
Received: 2 August 2019 / Revised: 7 September 2019 / Accepted: 11 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Antibiotic Allergies)
Macrolides are antimicrobial agents that can be used to treat a variety of infections. Allergic reactions to macrolides occur infrequently but can include minor to severe cutaneous reactions as well as systemic life-threatening reactions such as anaphylaxis. Most reports of allergic reactions occurred in patients without prior exposure to a macrolide. Cross-reactivity among macrolides may occur due to the similarities in their chemical structures; however, some published literature indicates that some patients can tolerate a different macrolide. Most published reports detailed an allergic reaction to erythromycin. Desensitization protocols to clarithromycin and azithromycin have been described in the literature. The purpose of this article is to summarize macrolide-associated allergic reactions reported in published literature. An extensive literature search was conducted to identify publications linking macrolides to hypersensitivity reactions. View Full-Text
Keywords: macrolides; allergy; azithromycin; erythromycin; clarithromycin; fidaxomicin; desensitization macrolides; allergy; azithromycin; erythromycin; clarithromycin; fidaxomicin; desensitization
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MDPI and ACS Style

Shaeer, K.M.; Chahine, E.B.; Varghese Gupta, S.; Cho, J.C. Macrolide Allergic Reactions. Pharmacy 2019, 7, 135.

AMA Style

Shaeer KM, Chahine EB, Varghese Gupta S, Cho JC. Macrolide Allergic Reactions. Pharmacy. 2019; 7(3):135.

Chicago/Turabian Style

Shaeer, Kristy M., Elias B. Chahine, Sheeba Varghese Gupta, and Jonathan C. Cho. 2019. "Macrolide Allergic Reactions" Pharmacy 7, no. 3: 135.

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