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Review

Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects

by
Andreea-Ina Antonescu (Mintas)
1,†,
Florina Miere (Groza)
2,†,
Luminita Fritea
2,*,
Mariana Ganea
2,
Mihaela Zdrinca
2,
Luciana Dobjanschi
2,
Angela Antonescu
2,*,
Simona Ioana Vicas
3,
Florin Bodog
2,
Rakesh K. Sindhu
4 and
Simona Cavalu
2
1
Faculty of Medicine and Pharmacy, Doctoral School of Biomedical Science, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
2
Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
3
Faculty of Environmental Protection, University of Oradea, 26 Gen. Magheru Street, 410048 Oradea, Romania
4
Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India
*
Authors to whom correspondence should be addressed.
†
Authors with equal contribution to this paper.
Plants 2021, 10(7), 1390; https://doi.org/10.3390/plants10071390
Submission received: 1 June 2021 / Revised: 28 June 2021 / Accepted: 5 July 2021 / Published: 7 July 2021
(This article belongs to the Special Issue Medicinal Plant Extracts)
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Abstract

Nowadays, the tendency in pharmaceutical and food industries is to replace synthetic antioxidants with the natural ones. For this reason, there is a growing interest in analyzing natural, healthy and non-toxic additives as potential antioxidants. Some plants, which contain high levels of phenolic compounds, present an increasing interest for medicine due to their ability to scavenge free radicals, along with other pharmacological activities, such as antibacterial activity, wound healing and anti-inflammatory effect, to mention only a few. The aim of this review is to explore the therapeutic potential of Ocimum basilicum and Trifolium pratense in relation with their phytochemical profile and to highlight the pharmacological activity of aqueous or ethanol extracts. Special attention was devoted to the dermal pathology and wound healing effects, in the context of multiple skin conditions such as acne, eczema boils, psoriasis and rashes. Additionally, both extracts (Trifolium sp. and Ocimum sp.) are characterized by high content of antioxidant compounds, which are responsible for the radiance and resistance of the skin and slowing down of the aging process by maintaining estrogen levels. Moreover, the potential combined effect of the mixed extract is pointed out in terms of future applications for wound healing, based on some preliminary results obtained from a “scratch tests” assay performed with respect to human dermal fibroblasts.
Keywords: Ocimum basilicum sp.; Trifolium pratense sp.; phytochemistry; antioxidant capacity; antibacterial activity; wound healing; anti-inflammatory Ocimum basilicum sp.; Trifolium pratense sp.; phytochemistry; antioxidant capacity; antibacterial activity; wound healing; anti-inflammatory

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MDPI and ACS Style

Antonescu, A.-I.; Miere, F.; Fritea, L.; Ganea, M.; Zdrinca, M.; Dobjanschi, L.; Antonescu, A.; Vicas, S.I.; Bodog, F.; Sindhu, R.K.; et al. Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects. Plants 2021, 10, 1390. https://doi.org/10.3390/plants10071390

AMA Style

Antonescu A-I, Miere F, Fritea L, Ganea M, Zdrinca M, Dobjanschi L, Antonescu A, Vicas SI, Bodog F, Sindhu RK, et al. Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects. Plants. 2021; 10(7):1390. https://doi.org/10.3390/plants10071390

Chicago/Turabian Style

Antonescu (Mintas), Andreea-Ina, Florina Miere (Groza), Luminita Fritea, Mariana Ganea, Mihaela Zdrinca, Luciana Dobjanschi, Angela Antonescu, Simona Ioana Vicas, Florin Bodog, Rakesh K. Sindhu, and et al. 2021. "Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects" Plants 10, no. 7: 1390. https://doi.org/10.3390/plants10071390

APA Style

Antonescu, A.-I., Miere, F., Fritea, L., Ganea, M., Zdrinca, M., Dobjanschi, L., Antonescu, A., Vicas, S. I., Bodog, F., Sindhu, R. K., & Cavalu, S. (2021). Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects. Plants, 10(7), 1390. https://doi.org/10.3390/plants10071390

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