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Communication

Anti-Inflammatory Activity of a Medicinal Herb Extract Mixture, HM-V, on an Animal Model of DNCB-Induced Chronic Skin Inflammation

1
Hanulmaum Oriental Medicine Clinic, Hanulmaum Oriental Medicine Laboratory, Seoul 06640, Korea
2
Department of Applied Chemistry, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin 17104, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Laura Grațiela Vicaș and Mariana Eugenia Mureșan
Plants 2021, 10(8), 1546; https://doi.org/10.3390/plants10081546
Received: 21 June 2021 / Revised: 26 July 2021 / Accepted: 26 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue Medicinal Plant Extracts)
Chronic inflammatory skin diseases, such as atopic dermatitis, are caused by the accumulation of immune cells and the overproduction of chemokines, including CCL17 and CCL22, due to the activation of pro-inflammatory cytokines secreted from keratinocytes. In the present study, the inhibitory activity of HM-V on tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ)-induced pro-inflammatory cytokines was examined in human keratinocytes (HaCaTs) and 2,4-dinitrofluorobenzene (DNCB)-induced chronic skin contact dermatitis animal models. Traditional Asian medicinal herb extracts mixture (HM-V), which have been extensively used in Asian medicine, were utilized. In TNF-α/IFN-γ-induced HaCaTs, HM-V strongly inhibited mRNA and protein expression of CCL17 and CCL22 in a concentration-dependent manner. The expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 was also inhibited. Therefore, localized administration of HM-V in the DNCB-induced animal model alleviated immune cell deposition and skin inflammation. The results indicate that HM-V exerts inhibitory effects on keratinocyte production of CCL17 and CCL22. Furthermore, HM-V may be a useful anti-inflammatory agent for the prevention and treatment of inflammatory skin diseases. View Full-Text
Keywords: chronic skin inflammation; medicinal herb extract; chemokine; contact dermatitis chronic skin inflammation; medicinal herb extract; chemokine; contact dermatitis
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MDPI and ACS Style

Park, S.; Lee, S.; Weon, Y.; Kim, T.; Kim, H.; Lee, T. Anti-Inflammatory Activity of a Medicinal Herb Extract Mixture, HM-V, on an Animal Model of DNCB-Induced Chronic Skin Inflammation. Plants 2021, 10, 1546. https://doi.org/10.3390/plants10081546

AMA Style

Park S, Lee S, Weon Y, Kim T, Kim H, Lee T. Anti-Inflammatory Activity of a Medicinal Herb Extract Mixture, HM-V, on an Animal Model of DNCB-Induced Chronic Skin Inflammation. Plants. 2021; 10(8):1546. https://doi.org/10.3390/plants10081546

Chicago/Turabian Style

Park, Sungbae, Sangmin Lee, Youngho Weon, Taewook Kim, Hakwon Kim, and Taehoon Lee. 2021. "Anti-Inflammatory Activity of a Medicinal Herb Extract Mixture, HM-V, on an Animal Model of DNCB-Induced Chronic Skin Inflammation" Plants 10, no. 8: 1546. https://doi.org/10.3390/plants10081546

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