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Article

Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System

1
Department of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 61242 Brno, Czech Republic
2
Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 61242 Brno, Czech Republic
3
Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
4
Department of Food Science, The Faculty of Agrobiology, Food and Natural Resources, The Czech University of Life Sciences Prague, 16500 Prague, Czech Republic
5
Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 61242 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(9), 468; https://doi.org/10.3390/biom9090468
Received: 1 July 2019 / Revised: 30 August 2019 / Accepted: 3 September 2019 / Published: 9 September 2019
The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo. View Full-Text
Keywords: stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages
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MDPI and ACS Style

Treml, J.; Leláková, V.; Šmejkal, K.; Paulíčková, T.; Labuda, Š.; Granica, S.; Havlík, J.; Jankovská, D.; Padrtová, T.; Hošek, J. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. Biomolecules 2019, 9, 468. https://doi.org/10.3390/biom9090468

AMA Style

Treml J, Leláková V, Šmejkal K, Paulíčková T, Labuda Š, Granica S, Havlík J, Jankovská D, Padrtová T, Hošek J. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. Biomolecules. 2019; 9(9):468. https://doi.org/10.3390/biom9090468

Chicago/Turabian Style

Treml, Jakub; Leláková, Veronika; Šmejkal, Karel; Paulíčková, Tereza; Labuda, Šimon; Granica, Sebastian; Havlík, Jaroslav; Jankovská, Dagmar; Padrtová, Tereza; Hošek, Jan. 2019. "Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System" Biomolecules 9, no. 9: 468. https://doi.org/10.3390/biom9090468

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