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Perspective

Role of Serum Amyloid A in Abdominal Aortic Aneurysm and Related Cardiovascular Diseases

1
Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
2
Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA
3
Barnstable Brown Diabetes Center, University of Kentucky, Lexington, KY 40536, USA
4
Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
5
Veterans Affairs Lexington, University of Kentucky, Lexington, KY 40536, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Limongelli
Biomolecules 2021, 11(12), 1883; https://doi.org/10.3390/biom11121883
Received: 9 November 2021 / Revised: 7 December 2021 / Accepted: 13 December 2021 / Published: 15 December 2021
Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field. View Full-Text
Keywords: cardiovascular disease; abdominal aortic aneurysm; serum amyloid A; HDL cardiovascular disease; abdominal aortic aneurysm; serum amyloid A; HDL
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MDPI and ACS Style

Shridas, P.; Patrick, A.C.; Tannock, L.R. Role of Serum Amyloid A in Abdominal Aortic Aneurysm and Related Cardiovascular Diseases. Biomolecules 2021, 11, 1883. https://doi.org/10.3390/biom11121883

AMA Style

Shridas P, Patrick AC, Tannock LR. Role of Serum Amyloid A in Abdominal Aortic Aneurysm and Related Cardiovascular Diseases. Biomolecules. 2021; 11(12):1883. https://doi.org/10.3390/biom11121883

Chicago/Turabian Style

Shridas, Preetha, Avery C. Patrick, and Lisa R. Tannock. 2021. "Role of Serum Amyloid A in Abdominal Aortic Aneurysm and Related Cardiovascular Diseases" Biomolecules 11, no. 12: 1883. https://doi.org/10.3390/biom11121883

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