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Article

Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity

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Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka 570 026, India
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Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570 015, India
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Department of Metallurgy and Materials Engineering, Malawi Institute of Technology, Malawi University of Science and Technology, P.O. Box 5916, Limbe 312229, Malawi
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ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Yelahanka, Bengaluru, Karnataka 560 064, India
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Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606, USA
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Department of Chemistry, Davangere University, Shivagangotri, Davangere, Karnataka 577 007, India
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Nature and Life Sciences, Earth and Universe Sciences, University of Tlemcen, Tlemcen 13000, Algeria
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Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia
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Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
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Authors to whom correspondence should be addressed.
Academic Editor: Simona Clichici
Biomolecules 2021, 11(3), 385; https://doi.org/10.3390/biom11030385
Received: 23 December 2020 / Revised: 23 February 2021 / Accepted: 24 February 2021 / Published: 5 March 2021
The present work describes a facile and convenient procedure for synthesizing zinc oxide nanoparticles using luteolin isolated from Eclipta alba plant (L-ZnONPs) at room temperature. The formation of as-grown L-ZnONPs was confirmed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and selected area electron diffraction (SAED). The Wurtzite structure of ZnO was observed by its hexagonal phases in diffraction patterns. The SEM images revealed the different sizes and morphologies of L-ZnONPs, with diameters between 12 and 25 nm. The HR-TEM result showed that the inter-planar distance between two lattice fringes was 0.262 nm, which coincides with the d-spacing of (002) and (101) lattice planes of the as-obtained material. The anticancer activity of L-ZnONPs against the breast cancer cell line MCF-7 was greater as compared to that of luteolin or ZnO alone. The mechanistic evaluation of such an activity carried out using in silico methods suggested that the anti-breast cancer activity of L-ZnONPs was mediated by polo-like kinase 1 (PLK1) proteins. View Full-Text
Keywords: luteolin; ZnONPs; in silico analysis; PLK1 proteins luteolin; ZnONPs; in silico analysis; PLK1 proteins
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MDPI and ACS Style

Kollur, S.P.; Prasad, S.K.; Pradeep, S.; Veerapur, R.; Patil, S.S.; Amachawadi, R.G.; S, R.P.; Lamraoui, G.; Al-Kheraif, A.A.; Elgorban, A.M.; Syed, A.; Shivamallu, C. Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity. Biomolecules 2021, 11, 385. https://doi.org/10.3390/biom11030385

AMA Style

Kollur SP, Prasad SK, Pradeep S, Veerapur R, Patil SS, Amachawadi RG, S RP, Lamraoui G, Al-Kheraif AA, Elgorban AM, Syed A, Shivamallu C. Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity. Biomolecules. 2021; 11(3):385. https://doi.org/10.3390/biom11030385

Chicago/Turabian Style

Kollur, Shiva P., Shashanka K. Prasad, Sushma Pradeep, Ravindra Veerapur, Sharanagouda S. Patil, Raghavendra G. Amachawadi, Rajendra P. S, Ghada Lamraoui, Abdulaziz A. Al-Kheraif, Abdallah M. Elgorban, Asad Syed, and Chandan Shivamallu. 2021. "Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity" Biomolecules 11, no. 3: 385. https://doi.org/10.3390/biom11030385

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