Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity

Kollur, Shiva Prasad; Prasad, Shashanka K.; Pradeep, Sushma; Veerapur, Ravindra; Patil, Sharanagouda S.; Amachawadi, Raghavendra G.; S, Rajendra Prasad; Lamraoui, Ghada; Al-Kheraif, Abdulaziz A.; Elgorban, Abdallah M.; Syed, Asad; Shivamallu, Chandan

doi:10.3390/biom11030385

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Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity

^1,*

²,

²,

³,

Sharanagouda S. Patil

⁴,

Raghavendra G. Amachawadi

⁵

Rajendra Prasad S

⁶,

Ghada Lamraoui

⁷,

Abdulaziz A. Al-Kheraif

⁸,

Abdallah M. Elgorban

⁹

Asad Syed

^9,* and

Chandan Shivamallu

^2,*

Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka 570 026, India

Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570 015, India

Department of Metallurgy and Materials Engineering, Malawi Institute of Technology, Malawi University of Science and Technology, P.O. Box 5916, Limbe 312229, Malawi

⁴

ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Yelahanka, Bengaluru, Karnataka 560 064, India

⁵

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606, USA

⁶

Department of Chemistry, Davangere University, Shivagangotri, Davangere, Karnataka 577 007, India

⁷

Nature and Life Sciences, Earth and Universe Sciences, University of Tlemcen, Tlemcen 13000, Algeria

⁸

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia

⁹

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia

Authors to whom correspondence should be addressed.

Academic Editor: Simona Clichici

Biomolecules 2021, 11(3), 385; https://doi.org/10.3390/biom11030385

Received: 23 December 2020 / Revised: 23 February 2021 / Accepted: 24 February 2021 / Published: 5 March 2021

(This article belongs to the Special Issue Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications)

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Abstract

The present work describes a facile and convenient procedure for synthesizing zinc oxide nanoparticles using luteolin isolated from Eclipta alba plant (L-ZnONPs) at room temperature. The formation of as-grown L-ZnONPs was confirmed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and selected area electron diffraction (SAED). The Wurtzite structure of ZnO was observed by its hexagonal phases in diffraction patterns. The SEM images revealed the different sizes and morphologies of L-ZnONPs, with diameters between 12 and 25 nm. The HR-TEM result showed that the inter-planar distance between two lattice fringes was 0.262 nm, which coincides with the d-spacing of (002) and (101) lattice planes of the as-obtained material. The anticancer activity of L-ZnONPs against the breast cancer cell line MCF-7 was greater as compared to that of luteolin or ZnO alone. The mechanistic evaluation of such an activity carried out using in silico methods suggested that the anti-breast cancer activity of L-ZnONPs was mediated by polo-like kinase 1 (PLK1) proteins. View Full-Text

Keywords: luteolin; ZnONPs; in silico analysis; PLK1 proteins

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Kollur, S.P.; Prasad, S.K.; Pradeep, S.; Veerapur, R.; Patil, S.S.; Amachawadi, R.G.; S, R.P.; Lamraoui, G.; Al-Kheraif, A.A.; Elgorban, A.M.; Syed, A.; Shivamallu, C. Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity. Biomolecules 2021, 11, 385. https://doi.org/10.3390/biom11030385

AMA Style

Kollur SP, Prasad SK, Pradeep S, Veerapur R, Patil SS, Amachawadi RG, S RP, Lamraoui G, Al-Kheraif AA, Elgorban AM, Syed A, Shivamallu C. Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity. Biomolecules. 2021; 11(3):385. https://doi.org/10.3390/biom11030385

Chicago/Turabian Style

Kollur, Shiva P., Shashanka K. Prasad, Sushma Pradeep, Ravindra Veerapur, Sharanagouda S. Patil, Raghavendra G. Amachawadi, Rajendra P. S, Ghada Lamraoui, Abdulaziz A. Al-Kheraif, Abdallah M. Elgorban, Asad Syed, and Chandan Shivamallu. 2021. "Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity" Biomolecules 11, no. 3: 385. https://doi.org/10.3390/biom11030385

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