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Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice

by 1,†, 1,2,†, 1, 1 and 1,2,3,*
1
Department of Sports Medicine and Science in Graduate School, Konkuk University, Gwangjin-gu, Seoul 05029, Korea
2
Physical Activity and Performance Institute (PAPI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea
3
Department of Physical Education, Konkuk University, Gwangjin-gu, Seoul 05029, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Peter Meikle
Metabolites 2021, 11(8), 553; https://doi.org/10.3390/metabo11080553
Received: 1 July 2021 / Revised: 19 August 2021 / Accepted: 19 August 2021 / Published: 21 August 2021
(This article belongs to the Section Animal Metabolism)
In this study, we investigated the effects of exogenous lactate administration before exercise on energy substrate utilization during exercise. Mice were divided into exercise control (EX) and exercise with lactate intake (EXLA) groups; saline/lactate was administered 30 min before exercise. Respiratory gas was measured during moderate intensity treadmill exercise (30 min). Immediately after exercise, blood, liver, and skeletal muscle samples were collected and mRNA levels of energy metabolism-related and metabolic factors were analyzed. At 16–30 min of exercise, the respiratory exchange ratio (p = 0.045) and carbohydrate oxidation level (p = 0.014) were significantly higher in the EXLA than in the EX group. Immediately after exercise, the muscle and liver glycogen content and blood glucose level of the EXLA group were lower than those of the EX group. In addition, muscle mRNA levels of HK2 (hexokinase 2; p = 0.009), a carbohydrate oxidation-related factor, were higher in the EXLA than in the EX group, whereas the expression of PDK4 (pyruvate dehydrogenase kinase 4; p = 0.001), CS (citrate synthase; p = 0.045), and CD36 (cluster of differentiation 36; p = 0.002), factors related to oxidative metabolism, was higher in the EX than in the EXLA group. These results suggest that lactate can be used in various research fields to promote carbohydrate metabolism. View Full-Text
Keywords: exogenous lactate; supplement; exercise; metabolism; carbohydrate oxidation exogenous lactate; supplement; exercise; metabolism; carbohydrate oxidation
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MDPI and ACS Style

Jang, I.; Kim, J.; Kyun, S.; Hwang, D.; Lim, K. Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice. Metabolites 2021, 11, 553. https://doi.org/10.3390/metabo11080553

AMA Style

Jang I, Kim J, Kyun S, Hwang D, Lim K. Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice. Metabolites. 2021; 11(8):553. https://doi.org/10.3390/metabo11080553

Chicago/Turabian Style

Jang, Inkwon, Jisu Kim, Sunghwan Kyun, Deunsol Hwang, and Kiwon Lim. 2021. "Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice" Metabolites 11, no. 8: 553. https://doi.org/10.3390/metabo11080553

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