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Gut Microbiota, Fusobacteria, and Colorectal Cancer

by 1,2, 3 and 2,3,4,*
Graduate Entry Medical School, University of Limerick, Limerick, Ireland
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Department of Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
Author to whom correspondence should be addressed.
Diseases 2018, 6(4), 109;
Received: 30 August 2018 / Revised: 9 November 2018 / Accepted: 4 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Gut Microbiome and Human Diseases)
The gut microbiota has emerged as an environmental contributor to colorectal cancer (CRC) in both animal models and human studies. It is now generally accepted that bacteria are ubiquitous colonizers of all exposed human body surfaces, including the entire alimentary tract (5). Recently, the concept that a normal bacterial microbiota is essential for the development of inflammation-induced carcinoma has emerged from studies of well-known colonic bacterial microbiota. This review explores the evidence for a role of fusobacteria, an anaerobic gram-negative bacterium that has repeatedly been detected at colorectal tumor sites in higher abundance than surrounding histologically normal tissue. Mechanistic studies provide insight on the interplay between fusobacteria, other gut microbiota, barrier functions, and host responses. Studies have shown that fusobacteria activate host inflammatory responses designed to protect against pathogens that promote tumor growth. We discuss how future research identifying the pathophysiology underlying fusobacteria colon colonization during colorectal cancer may lead to new therapeutic targets for cancer. Furthermore, disease-protective strategies suppressing tumor development by targeting the local tumor environment via bacteria represent another exciting avenue for researchers and are highlighted in this review. View Full-Text
Keywords: fusobacteria; colorectal cancer; carcinogenesis; microbiome fusobacteria; colorectal cancer; carcinogenesis; microbiome
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MDPI and ACS Style

Kelly, D.; Yang, L.; Pei, Z. Gut Microbiota, Fusobacteria, and Colorectal Cancer. Diseases 2018, 6, 109.

AMA Style

Kelly D, Yang L, Pei Z. Gut Microbiota, Fusobacteria, and Colorectal Cancer. Diseases. 2018; 6(4):109.

Chicago/Turabian Style

Kelly, Dervla, Liying Yang, and Zhiheng Pei. 2018. "Gut Microbiota, Fusobacteria, and Colorectal Cancer" Diseases 6, no. 4: 109.

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