Hop By-Products: Pharmacological Activities and Potential Application as Cosmetics
Round 1
Reviewer 1 Report
The paper submitted for review entitled: “Humulus lupulus L .: potential application as cosmetic” presents the possibilities of using post-production waste in the food industry. The possibilities of isolating active ingredients with a cosmetically active potential were indicated.
The paper concerns an interesting and extremely topical subject. However, it requires numerous corrections before possible publication in the journal: Cosmetics. The inconsistent way of writing is noteworthy. Very numerous repetitions and lack of care for the writing of Latin names in italics is also noteworthy
The title is not precise. Point out that the manuscript concerns the use of post-production waste and not the hops themselves.
Write the Latin name of the plant in italics.
Line 25: Confirm the correct linguistic statement: "When grown for beer"
Make sure you write about oil or essential oil (line 31).
Line 39 - do not use abbreviations that you have not explained before.
Correct the paragraph: Besides the application in the brewing industry, hops have for a long time been used for various medical purposes [9,10]. The beneficial effects of hop polyphenols in various chronic diseases, such as insomnia, inflammation, insulin, diabetes as well as in menopause and as antifungal, have been scientifically proven in many studies (Inui et al., 2017; Yin-Fang Yan et al. , 2021). In recent years, antioxidant and anti-inflammatory activities of the hop extracts have attracted attention and were widely [9,12]. Insulin - that's not the name of the disease!
review method is missing, chapter 3: review results - further elements should be sub-chapters of chapter 3.
Line 65: Repetitions
do the authors have any source that shows how much biomass is produced - it can be estimated based on the previous data shown in the introduction
Lines 72-75: this is a boost - but what - it has not been written what forms of extraction are used today and what are their limitations, since we should look for new, better ...
Line 81: reference off-topic, incorrect bibliometric notation!
od Linie 110: The chemical composition of spent yeast includes carbohydrates, proteins, free amino acids, ash, vitamins and minerals and fatty acids, constituting an excellent source of high-quality protein [21]. Twice about proteins.
113-146 repetition (even graphics twice the same).
Lines 158: when citing the research, please indicate only the first author et al. (Give the reference number in brackets).
Lines 161-164 - unnecessary information. However, there is no broader description of the phytochemical composition of the botanical raw material.
Lines 167-172 - delete as redundant information.
Lines 172-173 - duplication, no reference
Lines 176-178 - remove as redundant
Lines 181-190 - delete as redundant
Table 1 is unsightly and not prepared in accordance with the description of the publishing house's requirements. What is the purpose of adding origin information?
The table is to be self-describing - explain all abbreviations under the table
Description of the anti-inflammatory effect: explain whether you are writing about in vitro or in vivo research? Describe these studies in more detail.
line 247 - indicated reference 12 is not a source reference for this information.
line 252 - why do you use capital letters when writing about trial?
273 - reference writing error
Another mention of a given pot of microorganism - use the abbreviation
305 - Agnieszka is a first name, not a surname. There was also no reference to this citation
References 42 and 43 have incorrect bibliometric notation. Are they scientific or popular science?
Conclusions: totally unsatisfactory. Indicate what is the most important in this work! What are the practical conclusions of this review? What needs to be researched next?
Author Response
We appreciate the reviewer´s comments on our manuscript “Humulus lupulus L.: potential application as cosmetic”. According to that, we revised the original manuscript and the revisions are marked using the “Track Changes” function.
Referee 1 comment:
The paper submitted for review entitled: “Humulus lupulus L .: potential application as cosmetic” presents the possibilities of using post-production waste in the food industry. The possibilities of isolating active ingredients with a cosmetically active potential were indicated.
The paper concerns an interesting and extremely topical subject. However, it requires numerous corrections before possible publication in the journal: Cosmetics. The inconsistent way of writing is noteworthy. Very numerous repetitions and lack of care for the writing of Latin names in italics is also noteworthy
Authors answer:
The authors are grateful for thorough revision and valuable comments of Referee 1. We agree that it has some lacks and repetition on the manuscript. Accordingly, we correct the identified points. The conclusion was improved and the references revised.
Referee 1 comment:
The title is not precise. Point out that the manuscript concerns the use of post-production waste and not the hops themselves.
Authors answer:
In accordance to comment of Referee 1 we propose change the Title to “Hop by-products: pharmacological activities and potential application as cosmetic”
Referee 1 comment:
review method is missing, chapter 3: review results - further elements should be sub-chapters of chapter 3.
Authors answer:
The Materials and Methods topic was added to the manuscript and Chapter 3 reorganize as Results and Discussion
Referee 1 comment:
Lines 72-75: this is a boost - but what - it has not been written what forms of extraction are used today and what are their limitations, since we should look for new, better ...
Authors answer:
Some information was added at lines 93-95.
Referee 1 comment:
Table 1 is unsightly and not prepared in accordance with the description of the publishing house's requirements. What is the purpose of adding origin information?
The table is to be self-describing - explain all abbreviations under the table
Authors answer:
We rearranged and divided the Table in three distinct Tables, in which the origin information was removed as suggested by the referee.
Reviewer 2 Report
Can be published in cosmetics like it is,
Author Response
We appreciate the reviewer´s comments on our manuscript “Humulus lupulus L.: potential application as cosmetic”. According to that, we revised the original manuscript and the revisions are marked using the “Track Changes” function.
Referee 1 comment:
Can be published in cosmetics like it is,
Authors answer:
The authors are grateful for thorough revision and valuable comments of Referee 2.
Author Response File: 
Author Response.pdf
Reviewer 3 Report
The article presented on the potential use of hops as an ingredient with antioxidant properties in cosmetics is very interesting in relation to its antioxidant properties according to its origin and recent studies.
It is only necessary to mention the regulation that should be applied to this and other extracts of natural origin.
Author Response
Referee 3 comment:
The article presented on the potential use of hops as an ingredient with antioxidant properties in cosmetics is very interesting in relation to its antioxidant properties according to its origin and recent studies.
It is only necessary to mention the regulation that should be applied to this and other extracts of natural origin.
Authors answer:
The authors are grateful for thorough revision and valuable comments of Referee 3. Directive 2004/24/EC and EC 1223/2009 are mentioned in the manuscript (Lines 412-414).
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Thank you very much for the opportunity to recheck the paper titled: Hop by-products: pharmacological activities and potential application as cosmetic
The corrections made, in particular the removal of a large part of the repetitive text (and duplicate Figure 1), improved the quality of the manuscript. Unfortunately, not all fixes are satisfactory.
Graphic 1 is identical to the graphic in the paper quoted as 14. It is not an adaptation, but a reprint without any changes or modifications. Unless the authors have the written permission of the authors and publisher to reprint this graphic, it cannot be used in this manuscript. To point out that a reprint is an adaptation is, in my opinion, an unethical act.
The description of the review method needs to be improved. First of all, it should be noted that combinations of keywords were used and not the creation of new keys that are not allowed to appear in scientific databases, such as: ” hop skin care”
Botanical nomenclature: thanks for the corrections made. Additionally: the indication of the author of the botanical diagnosis (eg L from Linenaeus) should appear only once, at the first indication of a given name.
In some passages the terms alpha- and beta- acids appear. Please specify that it is a bitter acid
Chapter on the use of hop ingredients as cosmetics:
This is the chapter that, according to the title, should be the most important element of this study. Unfortunately, it is insufficient. There is no information about the effects of ingredients derived from hops as tyrosinase inhibitors, there is no indication of the use of extracts as deodorant ingredients, nothing about the effect on plaque. This indicates the need for a more detailed review of the scientific literature using the following keywords: hops AND cosmetic.
The last sentence of this chapter: concerning legislation, requires more extensive discussion and explanation. You can also indicate what potential damage hops extracts can cause to the skin.
Conclusions:
The first two sentences of the conclusion are redundant. Rest are not very precise. Please, indicate the specific conclusions resulting from the literature review, taking into account what is already known and where the ingredients obtained from hops should be located in cosmetic products, and which still requires scientific confirmation.
Author Response
[Cosmetics] Manuscript ID: cosmetics-2047928
Referee 1 comment:
Thank you very much for the opportunity to recheck the paper titled: Hop by-products: pharmacological activities and potential application as cosmetic
The corrections made, in particular the removal of a large part of the repetitive text (and duplicate Figure 1), improved the quality of the manuscript. Unfortunately, not all fixes are satisfactory.
Authors answer:
We appreciate your valuable comments in order to improve the quality of the manuscript.
Referee 1 comment:
Graphic 1 is identical to the graphic in the paper quoted as 14. It is not an adaptation, but a reprint without any changes or modifications. Unless the authors have the written permission of the authors and publisher to reprint this graphic, it cannot be used in this manuscript. To point out that a reprint is an adaptation is, in my opinion, an unethical act.
Authors answer:
Graphic 1 was changed (Line 111).
Referee 1 comment:
The description of the review method needs to be improved. First of all, it should be noted that combinations of keywords were used and not the creation of new keys that are not allowed to appear in scientific databases, such as: ” hop skin care”
Authors answer:
The review method was changed according the reviewer comments.
Referee 1 comment:
Botanical nomenclature: thanks for the corrections made. Additionally: the indication of the author of the botanical diagnosis (eg L from Linenaeus) should appear only once, at the first indication of a given name.
In some passages the terms alpha- and beta- acids appear. Please specify that it is a bitter acid
Authors answer:
We changed the manuscript according the reviewer comments.
Referee 1 comment:
Chapter on the use of hop ingredients as cosmetics:
This is the chapter that, according to the title, should be the most important element of this study. Unfortunately, it is insufficient. There is no information about the effects of ingredients derived from hops as tyrosinase inhibitors, there is no indication of the use of extracts as deodorant ingredients, nothing about the effect on plaque. This indicates the need for a more detailed review of the scientific literature using the following keywords: hops AND cosmetic.
The last sentence of this chapter: concerning legislation, requires more extensive discussion and explanation. You can also indicate what potential damage hops extracts can cause to the skin.
Authors answer:
We changed the manuscript according the reviewer comments (Lines 402 – 423; 437-446; 450-461)
Referee 1 comment:
Conclusions:
The first two sentences of the conclusion are redundant. Rest are not very precise. Please, indicate the specific conclusions resulting from the literature review, taking into account what is already known and where the ingredients obtained from hops should be located in cosmetic products, and which still requires scientific confirmation.
Authors answer:
We improve the conclusion. We hope that were according the reviewer comments.
Author Response File: Author Response.pdf
Round 3
Reviewer 1 Report
The third opportunity to read the text: Hop by-products: pharmacological activities and potential application as cosmetic shows its significant, beneficial changes. Thank you for responding to all my comments.
Minor changes to be made include only improving the quality of Graph 1.
The methodological description is not perfect but acceptable.
The chapter on the use of hops in cosmetics has been significantly expanded. The works cited here on antioxidant and antimicrobial activity (e.g. 46) carried out in in vitro models should be included in the relevant tables introduced earlier.
The conclusions, as currently presented, are fully satisfactory.
Thank you again for the corrections to the text.
Author Response
[Cosmetics] Manuscript ID: cosmetics-2047928
Referee 1 comment:
The third opportunity to read the text: Hop by-products: pharmacological activities and potential application as cosmetic shows its significant, beneficial changes. Thank you for responding to all my comments.
Authors answer:
We appreciate all your valuable comments in order to improve the quality of the manuscript.
Referee 1 comment:
Minor changes to be made include only improving the quality of Graph 1.
The chapter on the use of hops in cosmetics has been significantly expanded. The works cited here on antioxidant and antimicrobial activity (e.g. 46) carried out in in vitro models should be included in the relevant tables introduced earlier.
Authors answer:
The proposed changes were applied to the manuscript.
Author Response File: Author Response.pdf
