Next Article in Journal / Special Issue
Rhodomyrtus tomentosa Fruit Extract and Skin Microbiota: A Focus on C. acnes Phylotypes in Acne Subjects
Previous Article in Journal / Special Issue
Lake Zeiļu Clay Application Induced Changes in Human Skin Hydration, Elasticity, Transepidermal Water Loss and PH in Healthy Individuals
Open AccessArticle

Effective Transcutaneous Delivery of Hyaluronic Acid Using an Easy-to-Prepare Reverse Micelle Formulation

1
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan
2
Center for Future Chemistry, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan
3
Kobayashi Pharmaceutical Co., Ltd. 1-30-3 Toyokawa, Ibaraki, Osaka 567-0057, Japan
4
Advanced Transdermal Drug Delivery System Center, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(3), 52; https://doi.org/10.3390/cosmetics7030052
Received: 21 May 2020 / Revised: 27 June 2020 / Accepted: 28 June 2020 / Published: 1 July 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
The skin loses its moisture with advancing age, causing cosmetic issues such as wrinkles. In addition, the loss of moisture leads to hypersensitivity to external stimuli such as UV light. Transcutaneous supplementation with hyaluronic acid (HA) is an effective and safe method of recovering the moisturizing function and elasticity of the skin. However, the transcutaneous delivery of HA remains challenging owing to the barrier function of the stratum corneum (SC) layer. To penetrate the SC barrier, we used a reverse micelle formulation that does not require high energy consumption processes for preparation. We aimed to enhance the skin permeability of HA by incorporating glyceryl monooleate—a skin permeation enhancer—into the formulation. A fluorescently-labeled HA-loaded reverse micelle formulation showed significantly enhanced permeation across Yucatan micro pig skin. Fourier transform infra-red spectroscopy of the surface of the skin treated with the reverse micelle formulation showed blue shifts of the CH2 symmetric/asymmetric stretching peaks, indicating a reduction in the barrier function of the SC. Further study revealed that HA was released from the reverse micelles at the hydrophobic/hydrophilic interface between the SC and the living epidermis. The results demonstrated that our reverse micellar system is an easy-to-prepare formulation for the effective transcutaneous delivery of HA. View Full-Text
Keywords: cosmetics; biomedicine; transcutaneous drug delivery; hyaluronic acid; reverse micelle cosmetics; biomedicine; transcutaneous drug delivery; hyaluronic acid; reverse micelle
Show Figures

Figure 1

MDPI and ACS Style

Kozaka, S.; Kashima, A.; Wakabayashi, R.; Nakata, T.; Ueda, T.; Goto, M. Effective Transcutaneous Delivery of Hyaluronic Acid Using an Easy-to-Prepare Reverse Micelle Formulation. Cosmetics 2020, 7, 52.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop