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Protective Effects of Salicornia europaea on UVB-Induced Misoriented Cell Divisions in Skin Epithelium

1
Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima 727-0023, Japan
2
Research & Development Division, Pias Corporation, Kobe, Hyogo 651-2241, Japan
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 44; https://doi.org/10.3390/cosmetics7020044
Received: 7 May 2020 / Revised: 4 June 2020 / Accepted: 5 June 2020 / Published: 7 June 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Correct orientation of cell division is extremely important in the maintenance, regeneration, and repair of continuously proliferating tissues, such as the epidermis. Regulation of the axis of division of epidermal cells prevents the apoptosis-induced compensatory proliferation, and eventually the cancer. Thus, the orientation of cell division is critical for maintaining the tissue architecture. In this study, we investigated the effects of S. europaea extract on the texture of human skin and the behavior of these cells during skin morphogenesis. In sun-exposed skin, S. europaea improved the texture. A multilayered, highly differentiated in vitro skin model indicated that, S. europaea extract suppressed the UVB-induced changes in the morphology of basal keratinocytes. Orientation of cell division was determined by measuring the axis of mitosis in the vertical sections of our experimental model. Analyses of the digital images revealed that S. europaea preserved the axis of division of basal keratinocytes from UVB-induced perturbations. Our findings uncover a new mechanism by which S. europaea responds to the spindle misorientation induced by UVB. View Full-Text
Keywords: Salicornia europaea; Salicornia herbacea; coral grass; UVB; sun exposure; skin care; epidermal structure; cell polarity; axis of division; mitosis Salicornia europaea; Salicornia herbacea; coral grass; UVB; sun exposure; skin care; epidermal structure; cell polarity; axis of division; mitosis
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MDPI and ACS Style

Doi, N.; Togari, H.; Minagi, K.; Nakaoji, K.; Hamada, K.; Tatsuka, M. Protective Effects of Salicornia europaea on UVB-Induced Misoriented Cell Divisions in Skin Epithelium. Cosmetics 2020, 7, 44.

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