Background: There is some evidence showing significant correlations between acute chewing gum and orofacial function, and between acute chewing gum and cognitive function; however, as far as we are aware, little is known about the chronic effects of chewing gum training on cognitive and orofacial functions in healthy adults. Objectives: To evaluate the chronic effects of chewing gum training on orofacial and cognitive functions in healthy adults. Method: Searches of the electronic databases PubMed, Scopus, BVS, CENTRAL, Scopus, and Google Scholar were conducted from inception to 14 January 2020. The inclusion criteria used were: clinical trial or randomized controlled trial lasting a minimum of four weeks, chewing gum intervention in at least one arm of the study, presence of a non-exercise control group, study population consisting of healthy adults, study outcomes consisting of orofacial function and/or cognitive function. Results: Starting from 5973 sources, a total of six articles met the inclusion criteria, and they were subjected to a systematic review. The main findings were that chewing gum training improved some variables related to orofacial function. No clear effect of chewing gum training on cognitive function was found. Conclusions: Chronic chewing gum training has an unclear positive effect on specific variables related to orofacial and cognitive function in healthy adults.
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