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Open AccessArticle

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

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Eng4Life Srl, Spin-off Accademico, Via Fiorentino, 32, 83100 Avellino, Italy
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Dipartimento di Farmacia, Università degli Studi di Salerno, via Giovanni Paolo II, 132 84084 Fisciano (SA), Italy
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Dipartimento di Scienze della Vita—Centro Microscopia Elettronica, Università degli Studi di Trieste, via Fleming 31, A/B, 34127 Trieste, Italy
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Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, via Giovanni Paolo II, 132 84084 Fisciano (SA), Italy
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Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 22; https://doi.org/10.3390/cosmetics7020022
Received: 14 March 2020 / Revised: 1 April 2020 / Accepted: 1 April 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Novel nanotechnologies represent the most attractive and innovative tools to date exploited by cosmetic companies to improve the effectiveness of their formulations. In this context, nanoliposomes have had a great impact in topical preparations and dermocosmetics, allowing the transcutaneous penetration and absorption of several active ingredients and improving the stability of sensitive molecules. Despite the recent boom of this class of delivery systems, their industrial production is still limited by the lack of easily scalable production techniques. In this work, nanoliposomes for the topical administration of vitamin D3, K2, E, and curcumin, molecules with high antioxidant and skin curative properties but unstable and poorly absorbable, were produced through a novel simil-microfluidic technique. The developed high-yield semi continuous method is proposed as an alternative to face the problems linked with low productive conventional methods in order to produce antioxidant formulations with improved features. The novel technique has allowed to obtain a massive production of stable antioxidant vesicles of an 84–145 nm size range, negatively charged, and characterized by high loads and encapsulation efficiencies. The obtained products as well as the developed high-performance technology make the achieved formulations very interesting for potential topical applications in the cosmetics/cosmeceutical field. View Full-Text
Keywords: cosmeceutics; nanoliposomes; simil-microfluidic technology; antioxidants; transdermal delivery cosmeceutics; nanoliposomes; simil-microfluidic technology; antioxidants; transdermal delivery
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MDPI and ACS Style

Bochicchio, S.; Dalmoro, A.; De Simone, V.; Bertoncin, P.; Lamberti, G.; Barba, A.A. Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems. Cosmetics 2020, 7, 22.

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