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Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid

School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland SR13SD, UK
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Cosmetics 2019, 6(4), 59; https://doi.org/10.3390/cosmetics6040059
Received: 22 August 2019 / Revised: 14 September 2019 / Accepted: 16 September 2019 / Published: 1 October 2019
(This article belongs to the Special Issue Delivery Systems for Cosmetics)
Hyaluronic acid (HA) is a natural polysaccharide with promising applications in modern cosmetic and nutricosmetic products due to its high-water affinity, which is essential for skin hydration, as well as its biocompatibility, biodegradability, non-toxicity, and non-immunogenic nature. In this study, we investigated and optimized the method of crosslinking for formulating novel HA hydrogel films. We used Pentaerythritol Tetra-acrylate (PT) as the cross-linking agent over a range of pH values and used different cross-linking methods (Ultraviolet (UV) radiation, microwaving, and oven heating). The efficacy of the cross-linking reaction was evaluated using swelling studies and Fourier transform infrared (FTIR) spectroscopy for the characterization of the xerogel HA-PT film formulations. We found that HA-PT cross-linked hydrogels are produced under alkaline conditions (pH 11) but not under neutral or acidic conditions. Cross-linked HA-PT xerogel films using UV-irradiation showed excessive swelling indicative of inadequate cross-linking. The oven and microwaving methods produced HA-PT films with high cross-linking density. FTIR data suggest formation of ester bond between the carbonyl of the HA and hydroxyl group of the PT acrylate group. Overall, the oven method was considered better and easier than UV-radiation/microwave methods because it is safer, user-friendly and eco-friendly, and can process larger batches. View Full-Text
Keywords: Hyaluronic acid; Pentaerythritol Tetraacrylate; cross-linker; hydrogels; UV radiation; microwave; oven; FTIR; swelling; cosmetics Hyaluronic acid; Pentaerythritol Tetraacrylate; cross-linker; hydrogels; UV radiation; microwave; oven; FTIR; swelling; cosmetics
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MDPI and ACS Style

Rashid, F.; Albayati, M.; Dodou, K. Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid. Cosmetics 2019, 6, 59.

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