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The Potential Application of Spring Sargassum glaucescens Extracts in the Moisture-Retention of Keratinocytes and Dermal Fibroblast Regeneration after UVA-Irradiation
Open AccessBrief Report

Phytomelatonin Regulates Keratinocytes Homeostasis Counteracting Aging Process

1
EFFEGI LAB Srl Lavis (TN), 38015 Lavis TN, Italy
2
GalaScreen Srl University of Calabria-Italy, 87036 Calabria, Italy
3
Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Rende (CS), 87036 Rende, Italy
*
Author to whom correspondence should be addressed.
Cosmetics 2019, 6(2), 27; https://doi.org/10.3390/cosmetics6020027
Received: 25 March 2019 / Revised: 15 April 2019 / Accepted: 16 April 2019 / Published: 18 April 2019
(This article belongs to the Special Issue Anti-aging Properties of Natural Compounds)
Phytomelatonin (PM) gained the greatest interest for its application in agriculture and its use to improve human health conditions. PM based supplement has been shown to possess antioxidant capabilities because it functions as a free radical scavenger. Reactive Oxygen Species (ROS), induced by both intrinsic (peroxide production) and extrinsic (UV-radiation) factors are biochemical mediators crucial in skin aging. Skin aging is also regulated by specific microRNAs (miRs). Herein we have shown the effect of PM free radical scavengers on the human keratinocyte cell line HaCat and on ROS formation induced by both extrinsic and intrinsic factors as well as their capability to positively modulate a member of the hsa-miR-29 family linked to aging. Our result highlights the regulatory role of PM for the keratinocytes homeostasis. View Full-Text
Keywords: phytomelatonin; skin aging; microRNAs phytomelatonin; skin aging; microRNAs
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MDPI and ACS Style

Ferri, F.; Olivieri, F.; Cannataro, R.; Caroleo, M.C.; Cione, E. Phytomelatonin Regulates Keratinocytes Homeostasis Counteracting Aging Process. Cosmetics 2019, 6, 27.

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