Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models

Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology (COSMAST), University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy

Department of Animal Science, Plants for Human Health Institute, North Caroline State University, Kannapolis, NC 28081, USA

Department of Chemistry and Pharmaceutical Sciences University of Ferrara Via Fossato di Mortara 17, 44121 Ferrara, Italy

Author to whom correspondence should be addressed.

Cosmetics 2018, 5(4), 67; https://doi.org/10.3390/cosmetics5040067

Received: 12 September 2018 / Revised: 3 November 2018 / Accepted: 3 November 2018 / Published: 14 November 2018

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Abstract

Carnosine has several physiological roles, from intracellular pH buffering to antioxidant activities, which all depend on bioavailability. This study was conducted in a human skin 3D model and focuses on the effects of the topical delivery of carnosine, from a dermo-cosmetic gel, through the stratum corneum in the presence of a magnesium ion as a complexing agent. To evaluate possible enhancement for small peptide delivery to the skin from simple cosmetic formulations, we discovered that complexation was able to improve the delivery of carnosine into human skin 3D models by application in gel formulation. The concentrations of carnosine released in the underlying media and those that remained in the reconstructed human epidermis (RHE) tissues after 24 and 48 h exposure were measured. Moreover, the influence of magnesium ions was also evaluated comparing the same formulation with and without the salt. The results obtained in this study support hypothesis that magnesium can influence the delivery of small peptides and that the gel formulation based on the carnosine-magnesium complex allows for superior delivery of carnosine in the lower skin layer at a concentration up to 60% more than carnosine alone. View Full-Text

Keywords: carnosine; complexation; dermo-cosmetic formulation; topical delivery

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MDPI and ACS Style

Dissette, V.; Bignozzi, C.A.; Valacchi, G.; Pecorelli, A.; Manfredini, S.; Vertuani, S. Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models. Cosmetics 2018, 5, 67. https://doi.org/10.3390/cosmetics5040067

AMA Style

Dissette V, Bignozzi CA, Valacchi G, Pecorelli A, Manfredini S, Vertuani S. Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models. Cosmetics. 2018; 5(4):67. https://doi.org/10.3390/cosmetics5040067

Chicago/Turabian Style

Dissette, Valeria, Carlo A. Bignozzi, Giuseppe Valacchi, Alessandra Pecorelli, Stefano Manfredini, and Silvia Vertuani. 2018. "Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models" Cosmetics 5, no. 4: 67. https://doi.org/10.3390/cosmetics5040067

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Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models

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