Next Article in Journal
Water-Soluble Organic Germanium Promotes Both Cornified Cell Envelope Formation and Ceramide Synthesis in Cultured Keratinocytes
Next Article in Special Issue
Improving Skin Hydration and Age-related Symptoms by Oral Administration of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study
Previous Article in Journal
In Vitro Methods for Predicting Chemical Leukoderma Caused by Quasi-Drug Cosmetics
Previous Article in Special Issue
Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells
Article Menu

Export Article

Open AccessArticle
Cosmetics 2017, 4(3), 32;

In Vitro and In Vivo Evaluation of Nanoemulsion Containing Vegetable Extracts

Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Preto, SP 14040-903, Brazil
College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal, RN 59012-570, Brazil
Pharmacy Course Coordination, Centro Universitário Barão de Mauá, R. Ramos de Azevedo, 423, Jardim Paulista, Ribeirão Preto, SP 14090-180, Brazil
Author to whom correspondence should be addressed.
Received: 19 July 2017 / Revised: 7 August 2017 / Accepted: 29 August 2017 / Published: 7 September 2017
(This article belongs to the Special Issue Plant Extracts in Skin Care Products)
Full-Text   |   PDF [3154 KB, uploaded 7 September 2017]   |  
  |   Review Reports


Oil/Water nanoemulsions were obtained, employing PEG castor oil derivatives/fatty esters surfactant, babassu oil, and purified water from a study based on phase diagrams. The nanoemulsions had been prepared by a low energy process inversion phase emulsion. Different parameters, such as order of addition of the components, temperature, stirring speed, and time, were studied to prepare O/W nanoemulsions. The influence of vegetable extract addition on size distribution of nanoemulsions was also analyzed. Evaluation of the nanoemulsions was studied in vitro by HET-CAM and RDB methods. Stable transparent bluish O/W babassu oil nanoemulsion were obtained with surfactant pair fatty ester/PEG-54 castor oil, in an HLBrequired value = 10.0 and with a particle droplet size of 46 ± 13 nm. Vegetable extract addition had not influenced nanoemulsion’s stability. The results obtained for in vitro and in vivo nanoemulsion evaluation, based on the hydration and oiliness, and pH of the skin, shows O/W nanoemulsions as potential vehicle for topical application. View Full-Text
Keywords: nanoemulsions; babassu oil; vegetable extract; efficacy evaluation nanoemulsions; babassu oil; vegetable extract; efficacy evaluation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Rocha-Filho, P.A.; Ferrari, M.; Maruno, M.; Souza, O.; Gumiero, V. In Vitro and In Vivo Evaluation of Nanoemulsion Containing Vegetable Extracts. Cosmetics 2017, 4, 32.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Cosmetics EISSN 2079-9284 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top