In Vitro and In Vivo Evaluation of Nanoemulsion Containing Vegetable Extracts
1
Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Preto, SP 14040-903, Brazil
2
College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal, RN 59012-570, Brazil
3
Pharmacy Course Coordination, Centro Universitário Barão de Mauá, R. Ramos de Azevedo, 423, Jardim Paulista, Ribeirão Preto, SP 14090-180, Brazil
*
Author to whom correspondence should be addressed.
Cosmetics 2017, 4(3), 32; https://doi.org/10.3390/cosmetics4030032
Received: 19 July 2017
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Revised: 7 August 2017
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Accepted: 29 August 2017
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Published: 7 September 2017
(This article belongs to the Special Issue Plant Extracts in Skin Care Products)
Oil/Water nanoemulsions were obtained, employing PEG castor oil derivatives/fatty esters surfactant, babassu oil, and purified water from a study based on phase diagrams. The nanoemulsions had been prepared by a low energy process inversion phase emulsion. Different parameters, such as order of addition of the components, temperature, stirring speed, and time, were studied to prepare O/W nanoemulsions. The influence of vegetable extract addition on size distribution of nanoemulsions was also analyzed. Evaluation of the nanoemulsions was studied in vitro by HET-CAM and RDB methods. Stable transparent bluish O/W babassu oil nanoemulsion were obtained with surfactant pair fatty ester/PEG-54 castor oil, in an HLBrequired value = 10.0 and with a particle droplet size of 46 ± 13 nm. Vegetable extract addition had not influenced nanoemulsion’s stability. The results obtained for in vitro and in vivo nanoemulsion evaluation, based on the hydration and oiliness, and pH of the skin, shows O/W nanoemulsions as potential vehicle for topical application.
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Keywords:
nanoemulsions; babassu oil; vegetable extract; efficacy evaluation
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MDPI and ACS Style
Rocha-Filho, P.A.; Ferrari, M.; Maruno, M.; Souza, O.; Gumiero, V. In Vitro and In Vivo Evaluation of Nanoemulsion Containing Vegetable Extracts. Cosmetics 2017, 4, 32. https://doi.org/10.3390/cosmetics4030032
AMA Style
Rocha-Filho PA, Ferrari M, Maruno M, Souza O, Gumiero V. In Vitro and In Vivo Evaluation of Nanoemulsion Containing Vegetable Extracts. Cosmetics. 2017; 4(3):32. https://doi.org/10.3390/cosmetics4030032
Chicago/Turabian StyleRocha-Filho, Pedro Alves, Marcio Ferrari, Monica Maruno, Odila Souza, and Viviane Gumiero. 2017. "In Vitro and In Vivo Evaluation of Nanoemulsion Containing Vegetable Extracts" Cosmetics 4, no. 3: 32. https://doi.org/10.3390/cosmetics4030032
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